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E-book

Title MicroRNA : perspectives in health and diseases / edited by Jaishree Paul, Rohini Muthuswami
Published Boca Raton, FL : CRC Press, 2018

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Description 1 online resource (xiv, 202 pages)
Contents Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Foreword -- Preface -- Editors -- Contributors -- Chapter 1: Controlling the Biogenesis of the Smallest Regulators -- 1.1 Transcription of miRNA Genes -- 1.2 Factors Regulating the Transcription of miRNA Genes -- 1.3 Processing of the Primary miRNA Transcript -- 1.4 Control of miRNA Biogenesis -- 1.4.1 At the Nuclear Processing Step -- 1.4.2 Nuclear Export of Pre-miRNA -- 1.5 Processing of the Precursor miRNA Transcript -- 1.5.1 Control of miRNA Biogenesis at the Cytoplasmic Processing Step -- 1.5.2 RNA Induced Silencing Complex -- 1.5.3 Repression/Decay of Target mRNA -- 1.6 Conclusion -- REFERENCES -- Chapter 2: Computational Analysis of miRNAs, Their Target Sequences and Their Role in Gene Regulatory Networks -- 2.1 MiRBase -- 2.2 Computational Identification of miRNA Genes -- 2.2.1 Sequence and Structure Conservation -- 2.2.2 Machine Learning Approach -- 2.2.3 Experimental Data-Driven Approach -- 2.2.4 In-House Computational Pipelines -- 2.3 Computations in Target Prediction -- 2.4 miRNA and Gene Regulatory Network -- 2.5 Conclusion -- References -- Chapter 3: miRNAs: Small RNAs with Big Regulatory Functions in Parasitic Diseases -- 3.1 miRNAs: Small RNAs with Big Regulatory Functions -- 3.2 Intracellular Protozoan Pathogens -- 3.2.1 Alteration of Host miRNAs by Apicomplexans -- 3.2.1.1 Modulation of Host microRNome by Kinetoplastids -- 3.3 Extracellular Protozoan Parasites -- 3.4 MICRORNAs in Parasitic Helminthiases -- 3.5 Concluding Remarks -- References -- Chapter 4: Role of miRNA in Multiple Sclerosis -- 4.1 Role of Oligodendrocyte and miRNA -- 4.2 Role of Immune Cell in MS Pathogenesis -- 4.2.1 Role of Th Cell miRNAs in MS -- 4.2.2 Role of Treg Cell miRNAs in MS -- 4.3 Role of Viral miRNA in MS -- 4.4 Experimental Autoimmune Encephalomyelitis (EAE) Model
Summary This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed February 26, 2018)
Subject MicroRNA -- Health aspects
Small interfering RNA.
MicroRNA.
MicroRNAs
RNA, Small Interfering
SCIENCE -- Life Sciences -- Biochemistry.
MicroRNA
Small interfering RNA
Form Electronic book
Author Paul, Jaishree, editor.
Muthuswami, Rohini, editor
ISBN 9781351679879
1351679872
1351679880
9781351679886
1315166399
9781315166391