Title Micro-and Nanoelectromechanical Biosensors / Liviu Nicu, Thierry Leïchlé

Published Hoboken, NJ : Wiley ; London : ISTE Ltd., 2014

Table of Contents
	Introduction					vii
ch. 1	Transduction Techniques for Miniaturized Biosensors					1
1.1.	Definition of bioMEMS					1
1.2.	Transduction techniques					2
1.2.1.	Optical transduction					2
1.2.2.	Electro (chemical) transduction					6
1.2.3.	Mechanical-transduction					10
1.3.	MEMS transducers					17
1.4.	One specific application of MEMS-biosensors: detection of pathogen agents					20
1.5.	Bibliography					25
ch. 2	Bioreceptors and Grafting Methods					35
2.1.	Types of bioreceptor					35
2.1.1.	Catalytic receptors					36
2.1.2.	Affinity receptors					37
2.1.3.	Nucleic acid-based receptors					40
2.1.4.	Molecularly imprinted polymers					41
2.2.	Immobilization strategies					43
2.2.1.	Adsorption and antifouling strategies					44
2.2.2.	Entrapment methods					49
2.2.3.	Covalent coupling					51
2.2.4.	Other capture systems					54
2.2.5.	Immobilization strategies: summary					56
2.3.	Conclusion					57
2.4.	Bibliography					57
ch. 3	Patterning Techniques for the Biofunctionalization of MEMS					65
3.1.	What is surface patterning?					65
3.2.	Direct biopatterning in liquid phase					66
3.2.1.	Ink delivery by non-contact methods					67
3.2.2.	Ink delivery by contact methods					71
3.3.	Replication of patterns					80
3.3.1.	Photolithography					81
3.3.2.	Light-induced patterning strategies					81
3.3.3.	Microcontact printing					82
3.3.4.	In-flux functionalization					83
3.4.	Conclusions					84
3.5.	Bibliography					85
ch. 4	From MEMS to NEMS Biosensors					93
4.1.	Importance of downscaling					93
4.2.	Challenges faced by NEMS for biosensing applications					95
4.2.1.	Issues related to nanomechanical transducers					97
4.2.2.	Issues related to the functionalization of NEMS					99
4.2.3.	On the importance of packaging and sample preparation					103
4.3.	Economic considerations					106
4.4.	Bibliography					107
ch. 5	Comparing Performances of Biosensors: Impossible Mission?					113
5.1.	Bibliography					117
	Index					119

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Description 1 online resource Series FOCUS series Focus nanoscience and nanotechnology series. Contents Title Page; Copyright Page; Introduction; 1 Transduction Techniques for Miniaturized Biosensors; 1.1. Definition of BioMEMS; 1.2. Transduction Techniques; 1.3. MEMS Transducers; 1.4. One Specific Application of MEMS Biosensors: Detection of Pathogen Agents; 1.5. Bibliography; 2 Bioreceptors and Grafting Methods; 2.1. Types of Bioreceptor; 2.2. Immobilization Strategies; 2.3. Conclusion; 2.4. Bibliography; 3 Patterning Techniques for THE Biofunctionalization of Mems; 3.1. What is Surface Patterning?; 3.2. Direct Biopatterning in Liquid Phase; 3.3. Replication of Patterns 3.4. Conclusions3.5. Bibliography; 4 From Mems to Nems Biosensors; 4.1. Importance of Downscaling; 4.2. Challenges Faced by NEMS for Biosensing Applications; 4.3. Economic Considerations; 4.4. Bibliography; 5 Comparing Performances Of Biosensors: Impossible Mission?; 5.1. Bibliography; Index Summary Most books dedicated to the issues of bio-sensing are organized by the well-known scheme of a biosensor. In this book, the authors have deliberately decided to break away from the conventional way of treating biosensing research by uniquely addressing biomolecule immobilization methods on a solid surface, fluidics issues and biosensing-related transduction techniques, rather than focusing simply on the biosensor. The aim is to provide a contemporary snapshot of the biosensing landscape without neglecting the seminal references or products where needed, following the downscaling (from the mi Bibliography Includes bibliographical references and index Notes Text in English Print version record Subject Biosensors. Nanotechnology. Biosensing Techniques Nanotechnology TECHNOLOGY & ENGINEERING -- Mechanical. Biosensors Nanotechnology Form Electronic book Author Leichlé, Thierry, author. ISBN 9781118760857 1118760859 9781118760840 1118760840 9781118760987 1118760980 1306373689 9781306373685

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