Title The blood brain barrier (BBB) / Gert Fricker, Melanie Ott, Anne Mahringer, editors

Published Heidelberg : Springer, 2014

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Description 1 online resource (vii, 163 pages) : illustrations (some color) Series Topics in medicinal chemistry, 1862-2461 ; 10 Topics in medicinal chemistry (Springer (Firm)) ; 10. Contents Preface -- Contents -- The Blood-Brain Barrier: An Introduction to Its Structure and Function -- 1 The BBB: A Historical Perspective -- 2 Evolutionary Development of a BBB -- 3 Anatomic Principles of the BBB -- 4 Pericytes -- 5 Astrocyte: Endothelium Interactions -- 6 Neurons -- 7 Basal Membrane -- 8 Junctional Complexes at the BBB -- 9 Transport Proteins at the BBB -- 10 Cytotic Processes at the BBB -- 11 Outlook -- References -- In Vivo Approaches to Assessing the Blood-Brain Barrier -- 1 Introduction 2 Pharmacokinetic Principles of Blood-Brain Barrier Transport3 Methods -- 3.1 Brain Uptake Index (Carotid Artery Single Injection Technique) -- 3.2 The i.v. Injection Technique -- 3.3 In Situ Brain Perfusion -- 3.4 Brain Efflux Index -- 3.5 Percentage of the Injected Dose -- 3.6 Microdialysis -- 3.7 CSF Sampling -- 3.8 Positron Emission Tomography -- 3.9 Combinatorial Mapping of Kp, uu, brain -- 4 Conclusions -- References -- ABC Transporters at the Blood-Brain Barrier -- 1 Introduction -- 2 ABC Transporters at the Blood-Brain Barrier 2.1 Assessing ABC Transporter Activity/Expression3 Modulation of ABC Transporter Expression and Activity -- 3.1 Altered Transporter Expression -- 3.1.1 Response to Xenobiotics -- 3.1.2 Response to Disease -- 3.2 Altered Transporter Activity Through Signaling -- 3.2.1 Regulation of P-Glycoprotein Activity Through Sphingolipid Signaling -- 3.2.2 Regulation of P-Glycoprotein Activity Through VEGF Signaling -- 3.2.3 Regulation of BCRP Activity Through Estrogen Signaling -- 3.2.4 Mechanisms Underlying Decreased Transporter Activity -- 4 Perspectives -- References Nanoparticles as Blood-Brain Barrier Permeable CNS Targeted Drug Delivery Systems1 Introduction -- 1.1 Blood-Brain Barrier -- 1.2 Blood-Cerebrospinal Fluid Barrier (BCB) and CSF-Brain Barrier -- 1.3 CNS Drug Delivery Strategies -- 1.4 Nanomedicine Exploitation -- 1.5 Nanomedicines for BBB Crossing: General Considerations -- 2 BBB Crossing Nanocarriers -- 2.1 Poly(n-butylcyanoacrylate) (PBCA) NPs -- 2.2 Methoxypoly(ethylene glycol)-polylactide or Poly(lactide-co-glycolide) (mPEG-PLA/PLGA) NPs -- 2.3 Liposomes -- 2.4 Inorganic Nanosystems -- 3 Conclusions Summary Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors Analysis chemie chemistry geneeskunde medicine farmacologie pharmacology toxicologie toxicology Chemistry (General) Chemie (algemeen) Notes Includes index Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (SpringerLink, viewed November 14, 2014) Subject Blood-brain barrier. Blood-Brain Barrier -- physiology Blood-Brain Barrier -- physiopathology Drug Delivery Systems Blood-Brain Barrier SOCIAL SCIENCE -- Anthropology -- Physical. Blood-brain barrier Form Electronic book Author Fricker, Gert, 1956- editor. Ott, Melanie, editor. Mahringer, Anne, editor. ISBN 9783662437872 3662437872 3662437864 9783662437865

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