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Title Connexin cell communication channels : roles in the immune system and immunopathology / edited by Ernesto Oviedo-Orta, Brenda R. Kwak, William Howard Evans
Published Boca Raton : CRC Press, ©2013
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Description 1 online resource (363 pages)
Contents Front Cover; Contents; Preface; Editors; Contributors; Prequel: Gap Junctions, Hemichannels, and Cell-to-Cell Signalling; Chapter 1 -- Communication in the Immune System by Connexin Channels; Chapter 2 -- Gap Junctions and Connexins in the Hematopoietic-Immune System: Structural Considerations; Chapter 3 -- Approaches for Studying the Role(s) of Gap Junctions in the Immune System; Chapter 4 -- Gap Junctions in Antigen-Presenting Cells; Chapter 5 -- Connect the Immune System: Roles of Gap Junctions in Antigen Presentation and T Cell Activation
Chapter 13 -- Translating Basic Research on Cx43 Gap Junctions into Therapies for Reducing Scarring and Cardiac ArrhythmiaChapter 14 -- Connexin-Based Therapeutic Approaches to Inflammation in the Central Nervous System; Chapter 15 -- Enhancing Epithelial Tissue Repair and Reducing Inflammation by Targeting Connexins; Back Cover
Chapter 6 -- Gap Junctions and Connexins in the Immune Defense Against TumorsChapter 7 -- Connexins in Atherosclerosis; Chapter 8 -- Connexins in Lung Function and Inflammation; Chapter 9 -- Effect of Oxidative Stress on Connexins in the Vasculature; Chapter 10 -- Regulation of Gap Junctions and Cellular Coupling within the Microvasculature in Response to Acute Inflammation; Chapter 11 -- Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation; Chapter 12 -- A Role for Connexins in Inflammatory Disorders of the Epidermis
Summary Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in
Bibliography Includes bibliographical references and index
Notes Text in English
Subject Connexins -- immunology
Gap Junctions -- immunology
Inflammation -- physiopathology
Connexins -- Immunology
Gap junctions (Cell biology) -- Immunology
Inflammation -- Pathophysiology
Inflammation -- Pathophysiology.
SCIENCE -- Life Sciences -- Zoology -- General.
Form Electronic book
Author Evans, W. Howard
Kwak, Brenda R
Oviedo-Orta, Ernesto
ISBN 1439862583
9781439862582