Title Developmental plasticity of inhibitory circuitry / Sarah L. Pallas, editor

Published New York : Springer, ©2010

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Description 1 online resource (xi, 190 pages) : illustrations Contents Cover13; -- Preface -- Contents -- Contributors -- Chapter 1 Introduction -- 1.1 Hemifield Neglect? -- 1.2 8220;Inhibition8221; is Excitatory Early in Development -- 1.3 Mechanisms of Inhibitory Plasticity are Highly Diverse -- 1.3.1 Co-Transmitters -- 1.3.2 Changes in Receptor Subunit Composition -- 1.3.3 DSI -- 1.3.4 Inhibitory STDP -- 1.3.5 Receptor Trafficking -- 1.4 Homeostatic Plasticity -- 1.5 Critical Periods -- 1.6 Old Dogs and New Tricks: Adult Plasticity and Aging -- 1.7 Conclusions and Future Directions -- References -- Chapter 2 The Origins and Specification of Cortical Interneurons -- 2.1 Introduction -- 2.2 Origins of Cortical Interneurons -- 2.2.1 Medial Ganglionic Eminence -- 2.2.2 Caudal Ganglionic Eminence -- 2.2.3 Lateral Ganglionic Eminence -- 2.2.4 Rostral Migratory Stream -- 2.2.5 Septal Region -- 2.2.6 Cortex -- 2.3 Birthdating of Cortical Interneurons -- 2.4 Specification of Cortical Interneurons -- 2.4.1 Generation of Interneuron Diversity Within the MGE -- References -- Chapter 3 Role of Spontaneous Activity in the Maturation of GABAergic Synapses in Embryonic Spinal Circuits -- References -- Part II Systems -- Chapter 4 Regulation of Inhibitory Synapse Function in the Developing Auditory CNS -- 4.1 Spontaneous and Sound-Evoked Activity During Development -- 4.2 Perturbation of Auditory System Activity Alters Inhibition -- 4.3 Developmental Regulation of Inhibitory Synapses in the Lateral Superior Olive -- 4.4 Developmental Regulation of Inhibitory Synapse Gain in the Inferior Colliculus -- 4.5 Developmental Regulation of Inhibitory Synapse Gain in the Auditory Cortex -- 4.6 Summary -- 4.6.1 Heirarchical Modification of Inhibitory Function -- 4.6.2 Cellular Mechanisms that Regulate Inhibitory Gain -- 4.6.3 Effect of Inhibitory Gain on Auditory Processing -- References -- Chapter 5 Developmental Plasticity of Inhibitory Receptive Field Properties in the Auditory and Visual Systems -- 5.1 Introduction -- 5.1.1 Inhibitory Plasticity in the Hamster Superior Colliculus -- 5.1.2 Surround Inhibition Shapes Velocity Tuning in the SC -- 5.1.3 Effects of Modifying Retinocollicular Convergence on Surround Inhibition During Development -- 5.1.4 Surround Inhibition Plays a Larger Role in Velocity Tuning After Chronic NMDAR Blockade -- 5.1.5 Plasticity of Inhibition Underlying Vocalization Selectivity in the Auditory Cortex -- 5.1.6 Asymmetries in Sideband Inhibition Shape FM Rate and Direction Selectivity in Adults -- 5.1.7 Developmental Plasticity of Inhibition Underlying FM Rate and Direction Selectivity -- 5.1.8 Experience-Dependent Plasticity of Inhibition Shaping Rate and Direction Selectivity -- 5.1.9 Normal Experience is Required for the Maintenance of FM Rate Selectivity and HFI -- 5.1.10 Experience is Required for Development and Maintenance of Direction Selectivity and LFI -- 5.2 Discussion -- 5.2.1 The Contribution of Surround Inhibition to RF Properties Across Sensory Systems -- 5.2.2 Previous Studies on the Role of Inhibitory Plasticity in the Development of Response Selectivity -- 5.2.3 Homeostatic Plasticity of Inhibition: Beyond Response Magnitude Stability -- 5.2.4 Possible Synaptic Mechanisms of Plasticity in Strength and Timing of Inhibition -- 5.2.5 Role of Experience During Development: Maintenance Versus Refinement -- 5.2.6 Future Directions -- References -- Chapter 6 Postnatal Maturation and Experience-Dependent Plasticity of Inhibitory Circuits in Barrel Cortex Summary Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. However, experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. Only a few investigators have been engaged in research on how inhibitory circuits are formed during development or how they are involved in plasticity of developing sensory and motor circuitry. Developmental Plasticity of Inhibitory Circuitry approaches the subject of inhibitory plasticity from several levels of analysis, from synapses to circuits to systems to clinical, summarizing several possible mechanisms and collecting some of the most fascinating work in this under-studied area. It is meant to provide an overview for basic and clinical researchers and students interested in neural plasticity and to stimulate further research. About the Editor: Dr. Sarah L. Pallas is a Professor of Neuroscience and Biology at Georgia State University. She earned her Ph. D. in Neurobiology and Behavior at Cornell University, under the tutelage of Dr. Barbara Finlay. Her postdoctoral training was received at M.I.T. in the laboratory of Dr. Mriganka Sur. Her research concerns developmental neurobiology and sensory physiology, and in particular the role of sensory experience in the development and plasticity of neural circuits Bibliography Includes bibliographical references and index Notes Print version record In Springer eBooks Subject Neural circuitry. Neuroplasticity. Developmental neurobiology. Nervous System -- growth & development Neuronal Plasticity -- physiology Neurons -- physiology Nerve Net Neuronal Plasticity Rehabilitation pardons. SOCIAL SCIENCE -- Anthropology -- Physical. Biomédecine. Sciences de la vie. Developmental neurobiology Neural circuitry Neuroplasticity Form Electronic book Author Pallas, Sarah L. LC no. 2009932756 ISBN 9781441912435 1441912436 1282979477 9781282979475 1441912428 9781441912428

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