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Title Oral infections and general health : from molecule to chairside / Anne Marie Lynge Pedersen, editor
Published Cham : Springer, [2015]
Online access available from:
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Description 1 online resource (x, 149 pages) : illustrations (some color)
Contents About the Editor; Contents; Contributors; Part I: Background Topics; 1: Introduction; Part II: Oral Infections and General Health; 2: Dental Caries and General Health in Children and Adults; 2.1 Introduction; 2.2 Link between Caries and General Diseases; 2.3 Common Research Designs; 2.4 Obesity/Overweight; 2.5 Asthma; 2.6 Diabetes; 2.7 Congenital Heart Disease; 2.8 Cancers; 2.9 Cleft Lip Palate; 2.10 Neuropsychiatric Disorders; 2.11 Aging and Cognitive Impairment; 2.12 Caries Management; Conclusions; References
3: Plausible Mechanisms Explaining the Association of Periodontitis with Cardiovascular Diseases3.1 Introduction; 3.2 Definitions of the Conditions; 3.2.1 Periodontitis; 3.2.2 Atherosclerosis and Acute Atherosclerotic Events; 3.3 Bacteremia and Consequences for the Cardiovascular System; 3.4 Immunologic Reactions; 3.5 Pro-inflammatory State; 3.6 Prothrombotic State; 3.7 Dyslipidemia; 3.8 A Common Genetic Background; 3.9 Perspective and Concluding Remarks; References; 4: Linkage Between Periodontal Disease and Diabetes Mellitus; 4.1 Diabetes Mellitus
4.2 Association of Periodontitis and DM4.2.1 Population Data; 4.2.2 Biological Similarities; 4.2.3 Possible Mechanisms of Association; 4.2.4 Outcome of Periodontal Treatment; Conclusion; References; 5: Linkage Between Periodontal Disease and Rheumatoid Arthritis; 5.1 Rheumatoid Arthritis; 5.2 Association of Periodontitis and RA; 5.2.1 Population Data; 5.2.2 Biological Similarities; 5.2.3 Possible Mechanisms of Association; 5.2.4 Outcome of Periodontal Treatment; Conclusion; References; 6: Association Between Dental Infections and Renal and Liver Diseases; 6.1 Introduction
6.2 Renal Diseases6.3 Streptococcal Glomerulonephritis; 6.4 Liver Diseases; Conclusion; References; 7: Association Between Oral Infections and Cancer Risk; 7.1 Introduction; 7.2 Oral and Dental Infections and Cancer Epidemiology; 7.3 Infection-Driven Mechanisms in Carcinogenesis; 7.4 Acetaldehyde Production by Oral Microorganisms; 7.5 Caries, Periodontitis, and Cancer; 7.6 Role of Saliva in the Oral Infection-Linked Carcinogenesis; Conclusion; References; 8: Oral Candidiasis and the Medically Compromised Patient; 8.1 Introduction; 8.2 Clinicopathological Aspects
8.2.1 Histopathology8.2.2 Immunological Aspects; 8.3 Oral Candidiasis in the Medically Compromised Patient; 8.3.1 Oral Candidiasis as Adverse Drug Reaction; 8.3.2 Diabetes Mellitus and Oral Candidiasis; 8.3.3 HIV Infection and Oral Candidiasis; 8.3.4 Recipients of Organ and Haematopoietic Cell Transplants and Cancer Therapy; 8.4 Chronic Mucocutaneous Candidiasis; 8.5 Diagnostic Methods; 8.5.1 Culture of Clinical Samples in Order to Quantify and Identify the Candida Load; 8.5.2 Smears; 8.5.3 Biopsy; 8.5.4 Molecular Techniques for Candida Identification; References
Summary This book provides a wide-ranging update on the associations between oral infections and general health. Detailed consideration is given to the underlying mechanisms and pathways linking oral infections to general health, including metastatic spread of infection from the oral cavity as a result of transient bacteremia, metastatic injury from the effects of circulating oral microbial toxins, and metastatic inflammation caused by immunological dysfunction induced by oral microorganisms. The book also reviews the complex structure and development of oral biofilms in health and disease, and the molecular tools that are currently available for their analysis. The advantages and limitations of such techniques, as well as their impact on the future of diagnostics, prevention, and patient management, are discussed. The most common oral diseases can have significant implications for general health. For example, chronic oral infections, especially periodontitis, have been associated with diabetes, cardiovascular disease, and low birth weight. The microbial pathogenesis and etiology of dental caries, gingivitis, and chronic periodontitis have been comprehensively studied, and it is now generally accepted that these diseases occur as a result of the concerted actions of several microbial communities. In this regard, both the quantity and the quality of saliva play an essential role as the oral microbial composition and growth conditions are influenced by numerous salivary antimicrobial factors. Oral biofilms are complex and vary widely in composition, but improved knowledge of these biofilms holds the key to greater understanding of the disease processes and consequently the development of new preventive and therapeutic strategies
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed December 17, 2015)
Subject Mouth -- Infections.
Form Electronic book
Author Pedersen, Anne Marie Lynge, editor
ISBN 9783319250915 (electronic bk.)
3319250914 (electronic bk.)
3319250892 (print)
9783319250892 (print)