Nucleoside Transport Into Cells -- The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation -- Deoxynucleoside Kinases and Their Potential Role in Deoxynucleoside Cytotoxicity -- Nucleotidases and Nucleoside Analog Cytotoxicity -- Pumping Out Drugs -- Cytosine Arabinoside -- Clofarabine -- L-Nucleosides as Chemotherapeutic Agents -- Troxacitabine (Troxatyl ™) -- 9-?-D-Arabinofuranosylguanine -- Gemcitabine -- Clinical Activity of Gemcitabine as a Single Agent and in Combination -- Nucleoside Radiosensitizers -- NONMEM Population Models of Cytosine Arabinoside and Fludarabine Phosphate in Pediatric Patients With Leukemia -- ThecycloSal-Nucleotide Delivery System -- Purine and Pyrimidine-Based Analogs and Suicide Gene Therapy -- 3?-Deoxy-3?-Fluorothymidine as a Tracer of Proliferation in Positron Emission Tomography
Summary
Annotation Deoxynucleoside Analogs in Cancer Therapy discusses the classes of chemotherapeutic agents, and their analogs that are active against both common solid tumors and leukemias