| Description |
1 online resource (lix, 4638 pages) : illustrations (some color) |
| Contents |
Intro -- Preface to the Third Edition -- Neuroscience Addresses Medical and Public Health Problems, Worldwide -- Preface to the Second Edition -- Neuroscience Addresses Medical and Public Health Problems, Worldwide -- Preface to the First Edition -- Neuroscience Addresses Medical and Public Health Problems, Worldwide -- Further Reading -- Editors-in-Chief -- Supervisory Editors -- Contents -- Contributors -- Part I: Basic Neuroscience: Biophysics -- 1 Voltage-Gated Ion Channels -- Brief History -- Introduction -- Voltage-Gated Ion Channels are Multimeric Protein Complexes |
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Changes in the Conformation of the Pore-Forming Subunits Determine the State of the Channel -- VGSC States and Na+ Current Properties -- Modulation of Voltage-Gated Ion Channels Function -- Abnormalities in Voltage-Gated Ion Channel Functions Can Result in Human Disease -- Voltage-Gated Ion Channels are Targets of Therapeutic Agents -- Outlook -- Cross-References -- References -- 2 Water, Ions, Membranes, Pumps, and Transporters -- Brief History -- Water -- Water as a Solvent -- Membranes -- Pumps and Pores -- The Resting Membrane Potential -- Electrical Models of the Cell Membrane |
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Homeostasis Versus Electrical Excitability -- Outlook -- Glossary -- References -- 3 Ionotropic Glutamate Receptors (and Their Role in Health and Disease) -- Brief History -- Why Does the Brain Need Ligand-Gated Ion Channels? -- From the Primary to the 3D Structure of Ionotropic Glutamate Receptors -- Primary Structure -- Secondary Structure -- 3D Structure -- The Physiological Function of Ionotropic Glutamate Receptors in Rodents -- Primary Function -- Orphan Receptors -- Kainate Receptors -- AMPA Receptors -- NMDA Receptors -- AMPA and NMDA Receptors in Learning and Memory |
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The NMDA Receptor Function of Coincidence Detection in Learning -- Function of AMPA and NMDA Receptors in the Behavior of Experimental Animals -- NMDA Receptor Dysfunction During Development -- NMDA Receptor Hypofunction -- NMDA Receptor Hyperfunction -- Conditional NMDA Receptor Knockouts -- AMPA Receptor Gene-Targeted Mice -- AMPA and NMDA Receptor Dysfunction in CNS Disorders -- Auxiliary Subunits of iGluRs -- AMPA and NMDA Receptor Interactors in the Postsynaptic Density -- Outlook -- Cross-References -- References -- 4 Signal Transduction-Dependent Channels -- Brief History -- Introduction |
| Summary |
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimers and other dementias. Because neuroscience takes the etiology of diseasethe complex interplay between biological, psychological, and sociocultural factorsas its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21stCentury in its third edition serves as a comprehensive resource to students and researchers alike |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed October 31, 2022) |
| Subject |
Neurosciences.
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Neurosciences
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Neurosciences
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| Form |
Electronic book
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| Author |
Pfaff, Donald W., 1939- editor.
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Volkow, Nora D., 1956- editor.
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Rubenstein, John L. R., 1955- editor.
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| ISBN |
9783030888329 |
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3030888320 |
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