| Description |
1 online resource |
| Contents |
Part 1. DETERMINANT FEATURES IN LEISHMANIASIS -- Molecular Evolution and Phylogeny of Leishmania / Gabriele Schönian, Elisa Cupolillo and Isabel Mauricio -- The Role of Reservoirs: Canine Leishmaniasis / Lenea Campino and Carla Maia -- Epidemiology of Leishmaniasis in the Time of Drug Resistance / Jean-Claude Dujardin and Saskia Decuypere -- Introduction: Leishmaniasis -- The Biology of a Parasite / A. Ponte-Sucre |
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Part 2. Leishmania and the Immune System -- The Role of the Immune System in Resistance to Infection / Lukasz Kedzierski and Krystal J. Evans -- Vaccination as a Control Measure / Katrin Färber and Heidrun Moll -- Leishmania Vaccines: Past, Present, and Future / Bhavana Sethu Lakshmi and Rentala Madhubala |
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Part 3. CHALLENGES IN THE DIAGNOSIS, TREATMENT AND CONTROL OF LEISHMANIASIS IN TIMES OF DRUG RESISTANCE -- Co-infection with HIV / Margriet den Boer, Luis Rivas and Jorge Alvar -- Visceral Leishmaniasis / Shyam Sundar and Jaya Chakravarty -- American Tegumentary Leishmaniasis / Olga Zerpa and Alicia Ponte-Sucre |
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Part 4. MOLECULAR FEATURES OF DRUG-RESISTANT LEISHMANIA -- Genetic Expression and Drug Resistance, the Role of Proteomics / Patricia Cuervo and Jose Batista de Jesus -- The Role of ABC Transporters in Drug-Resistant Leishmania / Adriano C. Coelho and Paulo C. Cotrim -- Functional Analysis of Leishmania Membrane (Non-ABC) Transporters Involved in Drug Resistance / Scott M. Landfear -- Intracellular Mechanisms of Resistance / Mitali Chatterjee |
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Part 5. PHARMACOLOGY AND CHEMOTHERAPY OF LEISHMANIASIS -- Classical Versus Novel Treatment Regimens / Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos and Vanessa Yardley -- Drug Targets, Drug Effectors, and Drug Targeting and Delivery / Philippe M. Loiseau and Gillian Barratt -- Mechanisms of Miltefosine Resistance in Leishmania / Francisco Gamarro, María P. Sánchez-Cañete and Santiago Castanys -- P-glycoprotein-like Transporters in Leishmania: A Search for Reversal Agents / Bruno Pradines |
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Part 6. STRATEGIES TO CIRCUMVENT DRUG RESISTANCE IN LEISHMANIA -- The Relevance of Susceptibility Tests, Breakpoints, and Markers / Louis Maes, Paul Cos and Simon L. Croft -- The Concept of Fitness and Drug Resistance in Leishmania / Alicia Ponte-Sucre, Emilia Diaz and Maritza Padrón-Nieves |
| Summary |
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide |
| Analysis |
Medicine |
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Vaccines |
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Medical parasitology |
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Pharmaceutical technology |
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Emerging infectious diseases |
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Infectious Diseases |
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Drug Resistance |
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Parasitology |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| In |
Springer eBooks |
| Subject |
Leishmaniasis.
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Drug resistance in microorganisms.
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Medical parasitology.
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Drug resistance.
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Leishmaniasis
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Drug Resistance
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Leishmania -- drug effects
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HEALTH & FITNESS -- Diseases -- Contagious.
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MEDICAL -- Infectious Diseases.
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Médecine.
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Drug resistance
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Drug resistance in microorganisms
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Leishmaniasis
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Medical parasitology
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| Form |
Electronic book
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| Author |
Ponte-Sucre, Alicia.
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Diaz, Emilia.
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Padrón-Nieves, Maritza.
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| ISBN |
9783709111253 |
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3709111250 |
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3709102383 |
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9783709102381 |
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