| Description |
1 online resource (ix, 149 pages) |
| Series |
2011 Springer E-Books
|
| Contents |
Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches. ¡ |
| Summary |
Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
Enzyme kinetics -- Mathematical models
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Enzyme kinetics -- Data processing
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Pharmacokinetics.
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Mathematical models.
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Enzymes -- pharmacokinetics
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Pharmacokinetics
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Mathematical Computing
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Models, Theoretical
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mathematical models.
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Pharmacokinetics
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Mathematical models
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Enzyme kinetics -- Mathematical models
|
| Form |
Electronic book
|
| ISBN |
9783642208201 |
|
3642208207 |
|
9783642208195 |
|
3642208193 |
|
