| Description |
1 online resource (xi, 191 pages) : illustrations |
| Series |
Computational biology, 1568-2684 ; v. 9 |
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Computational biology ; v. 9.
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| Contents |
Experimental methods for protein interaction identification and characterization / Peter Uetz, Björn Titz, and Gerard Cagney -- Handling diverse protein interaction data: integration, storage and retrieval / Benjamin Shoemaker and Anna Panchenko -- Principles of protein recognition and properties of protein-protein interfaces / Ozlem Keskin, Attila Gursoy, and Ruth Nussinov -- Computational methods to predict protein interaction partners / Alfonso Valencia and Florencio Pazos -- Protein interaction network based prediction of domain-domain and domain-peptide interactions / Katia S. Guimarães and Teresa M. Przytycka -- Integrative structure determination of protein assemblies by satisfaction of spatial restraints / Frank Alber, Brian T. Chait, Michael P. Rout, and Andrej Sali -- Topological and dynamical properties of protein interaction networks / Sergei Maslov -- From protein interaction networks to protein function / Mona Singh -- Cross-species analysis of protein-protein interaction networks / Nir Yosef, Eytan Ruppin, and Roded Sharan |
| Summary |
The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse and present numerous challenges to modern biomolecular research because of their complexity. Analysis of patterns and principles governing these interactions has prompted a rapid development of computational methods to identify protein interaction partners and to understand the roles of individual components of protein interaction networks in cell functions. This book integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks. It brings together the descriptions of experimental techniques and expounds on different computational algorithms for protein network analysis and prediction of protein and domain interactions, with each chapter containing a description of the problem, a review of methods and algorithms, a list of resources and current conclusions. Features - Reviews experimental techniques for identification of protein interactions - Discusses protein interaction databases and methods of integrating data from diverse sources - Describes computational methods to predict protein and domain interaction partners - Explores the properties of interaction interfaces and highlights approaches to model the assembly of protein complexes - Examines the topological and dynamical properties of protein interaction networks and presents the tools for comparative analysis of these networks Written by leading experts, Protein-protein Interactions and Networks provides a broad, thorough and multidisciplinary coverage of this field. It will be invaluable to researchers from academia and the bioinformatics industry, as well as an excellent auxiliary text for graduate students studying the topic |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Protein-protein interactions.
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Bioinformatics.
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Computational biology.
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Proteins -- physiology
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Computational Biology
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SCIENCE -- Life Sciences -- Biochemistry.
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Informatique.
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Computational biology
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Bioinformatics
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Protein-protein interactions
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Molekulare Bioinformatik
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| Form |
Electronic book
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| Author |
Panchenko, Anna.
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Przytycka, Teresa.
|
| ISBN |
9781848001251 |
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1848001258 |
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1282824066 |
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9781282824065 |
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