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Title Treatment strategy for unexplained infertility and recurrent miscarriage / Keiji Kuroda, Jan J. Brosens, Siobhan Quenby, Satoru Takeda, editors
Published Singapore : Springer, 2018
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Contents Intro; Preface; Contents; Part I: Unexplained Infertility; Chapter 1: Unexplained Infertility: Introduction; References; Chapter 2: Fertilization Failure; 2.1 Introduction; 2.2 Fertilization Failure; 2.3 Treatment Strategy for Fertilization Failure; 2.3.1 Intracytoplasmic Sperm Injection (ICSI); 2.3.2 Assisted Oocyte Activation (AOA); 2.3.2.1 Mechanical Activation; 2.3.2.2 Chemical Activation; 2.3.2.3 Electrical Activation; 2.3.2.4 PLCZ1 mRNA Injection; 2.4 Conclusions; References; Chapter 3: Tubal Function Abnormalities with Tubal Patency in Unexplained Infertility
3.1 Oviduct Anatomy and Disorders3.2 Oviduct Function and Disorders; 3.2.1 Transportation of Gametes and Embryos; 3.2.2 Protection Against Heat Stress, Oxidative Stress, and Maternal Immune Response; 3.2.3 Capacitation; 3.2.4 Embryo Development; 3.3 Candidate Causes of Tubal Dysfunction in Unexplained Infertility; 3.3.1 Oocyte Capture Dysfunction in Tubal Fimbriae; 3.3.2 Transportation Failure of Gametes or Embryos; 3.3.3 Endometriosis; 3.3.4 Smoking; 3.4 Treatment Strategies; 3.4.1 Endoscopic Surgery; 3.4.2 Superovulation with Gonadotropins and Intrauterine Insemination
3.4.3 In Vitro Fertilization3.5 Conclusion; References; Chapter 4: Implantation Failure 1: Intrauterine Circumstances and Embryo-Endometrium Synchrony at Implantation; 4.1 Chronic Endometritis; 4.2 Cesarean Scar Syndrome; 4.3 Embryo-Endometrial Asynchrony (Impaired Decidualization of the Endometrium); References; Chapter 5: Implantation Failure 2: Immunomodulating Treatment for the Patients with Repeated Implantation Failures Caused by Immunological Rejection; 5.1 Introduction; 5.2 The Theoretical Mechanisms for Using Immunomodulation Drug; 5.3 Glucocorticoids; 5.4 Heparin Treatment
6.3.2 Control of Implantation Site6.3.3 Optimization of Window of Implantation; 6.3.4 Regulation of Immune Tolerance; 6.3.5 Treatment Strategy for Recurrent Implantation Failure; References; Part II: Unexplained Recurrent Miscarriage; Chapter 7: Unexplained Recurrent Miscarriage: Introduction; References; Chapter 8: Previous Trial Studies of Unexplained Recurrent Miscarriage; 8.1 Introduction; 8.2 Anticoagulants; 8.2.1 Low-Dose Aspirin (LDA); 8.2.2 Low-Molecular-Weight Heparin (LMWH); 8.3 Immunological Regulator; 8.3.1 The Effect of Maternal Immunity on Pregnancy Loss
Summary This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft. Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected. This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments
Notes Online resource; title from PDF title page (SpringerLink, viewed June 19, 2018)
Subject Infertility, Female -- Treatment.
Miscarriage.
Infertility, Female.
Form Electronic book
Author Brosens, Jan J., editor
Kuroda, Keiji, editor
Quenby, Siobhan, editor
Takeda, Satoru, editor
ISBN 9789811086908 (electronic bk.)
9811086907 (electronic bk.)
(print)