| Description |
1 online resource (451 pages) |
| Series |
River Publishers series in research and business chronicles : biotechnology and medicine ; v. 5 |
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River Publishers series in research and business chronicles: biotechnology and medicine ; v. 5.
|
| Contents |
Drug discovery : diseases, drugs and targets / Kishore R Sakharkar, Meena K Sakharkar and Ramesh Chandra -- Target identification and validation in microbial genomes / Koshire R Sakharkar, Meena K Sakharkar, Deepak Perumal, Ramesh Chandra and Chow T.K Vincent -- Prioritization analysis of disease association by data-mining of functional annotation of human genes / Nicki Tiffin and Junaid Gamieldien -- Genomics-guided discovery of novel therapeutics of actinobacterial origin / Janmejay Pandey and Surendra Nimesh -- Chemogenomics approach to computer aided drug discovery / Varun Khanna and Shoba Ranganathan -- network biology methods for drug repositioning / Cheng Zhu, Chao Wu and Anil G Jegga -- Hypothesis driven multi-target drug design / Prem kumar Jayaraman, Mohammad Imran Siddiqi, Meena K Sakharkar, Ramesh Chandra and Kishore R Sakharkar -- Genomics in vaccine development / Lars Rønn Olsen, Jing Sun, Christian Simon, Guang Lan Zhang and Valdimir Brusic -- Toward the computer-aided discovery and design of epitope ensemble vaccines / Nilay Mahida, Martin Blythe, Matthew N Davies, Irini A Doytchinova and Darren R Flower -- Vaccine discovery and translation of new vaccine technology / Rino Rappuoli, John L Telford and Roberto Rosini -- Outer membrane proteins as potential candidate vaccine targets / Yuka Hara and Sheiila Nathan -- Systems biology approaches to new vaccine development / Jing Sun, Guang Lan Zhang and Vladimir Brusic -- Inhibition of virulence potential of Vibrio Cholerae by herbal compounds / Sinosh Skariyachan -- In silico approaches for dealing with gene regulatory networks to understand molecular mechanisms of immunity in infectious disease / Milsee Mol and Shailza Singh -- Statistical models to predict drug side-effects / Yoshihiro Yamanishi |
| Summary |
Over the past decade genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: * Drug discovery * Target identification and prioritization * Hypothesis driven multi-target drug design * Genomics in vaccine development * Gene regulatory networks * Vaccine design and development * Prediction of drug side effects in silico |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Kishore R. Sakharkar, Meena K. Sakharkar, Ramesh Chandra |
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Print version record |
| Subject |
Drug development.
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Drugs -- Design.
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Drugs -- Side effects.
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Vaccines.
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Drug Design
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Drug Discovery
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Vaccines
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Drug-Related Side Effects and Adverse Reactions
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SCIENCE / Energy
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Vaccines
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Drug development
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Drugs -- Design
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Drugs -- Side effects
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| Form |
Electronic book
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| Author |
Sakharkar, Kishore R., editor
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Sakharkar, Meena K., editor
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Ramesh Chandra, editor
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| ISBN |
9788793102859 |
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8793102852 |
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9781003339090 |
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1003339093 |
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9781000795714 |
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1000795713 |
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9781000792393 |
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1000792390 |
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