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Title Monoclonal antibody and peptide-targeted radiotherapy of cancer / edited by Raymond M. Reilly
Published Hoboken, N.J. : Wiley, [2010]
©2010
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Description 1 online resource
Contents Antibody engineering : optimizing the delivery vehicle / Diane Milenic -- The radiochemistry of monoclonal antibodies and peptides / Raymond M. Reilly -- The design of radiolabeled peptides for targeting malignancies / Leonard G. Luyt -- Peptide receptor radionuclide therapy in patients with somatostatin receptor-positive neuroendocrine tumors / Martijn van Essen [and others] -- Targeted radiotherapy of CNS malignancies / Michael R. Zalutsky, David A. Reardon, and Darrell D. Bigner -- Radioimmunotherapy for B-cell non-Hodgkin lymphoma / Thomas E. Witzig -- Radioimmunotherapy of acute myeloid leukemia / Todd L. Rosenblat and Joseph G. Jurcic -- Pre-targeted radioimmunotherapy of solid tumors / Robert M. Sharkey and David G. Goldenberg -- Targeted auger electron radiotherapy of malignancies / Raymond M. Reilly and Amin Kassis -- Viral introduction of receptors for targeted radiotherapy / Kathryn Ottolino-Perry and J. Andrea McCart -- Preclinical cell and tumor models for evaluating radio-pharmaceuticals in oncology / Ann F. Chambers [and others] -- Radiation biology of targeted radiotherapy / David Murray and Michael Weinfeld -- Dosimetry for targeted radiotherapy / Sui Shen -- The bystander effect in targeted radiotherapy / Carmel Mothersill and Colin Seymour -- The role of molecular imaging in evaluating tumor response to targeted radiotherapy / Norbert Avril -- The economic attractiveness of targeted radiotherapy : value for money? / Jeffrey S. Hoch -- Selected regulatory elements in the development of cancer targeted protein and peptide radiotherapeutic agents / Thomas R. Sykes and Connie J. Sykes
Frontmatter -- Color Plates -- Antibody Engineering: Optimizing the Delivery Vehicle / Diane E Milenic -- The Radiochemistry of Monoclonal Antibodies and Peptides / Raymond M Reilly -- The Design of Radiolabeled Peptides for Targeting Malignancies / Leonard G Luyt -- Peptide Receptor Radionuclide Therapy in Patients with Somatostatin Receptor-Positive Neuroendocrine Tumors / Martijn van Essen, Dik J Kwekkeboom, Wouter W de Herder, Lisa Bodei, Boen L R Kam, Marion de Jong, Roelf Valkema, Eric P Krenning -- Targeted Radiotherapy of Central Nervous System Malignancies / Michael R Zalutsky, David A Reardon, Darell D Bigner -- Radioimmunotherapy for B-Cell Non-Hodgkin Lymphoma / Thomas E Witzig -- Radioimmunotherapy of Acute Myeloid Leukemia / Todd L Rosenblat, Joseph G Jurcic -- Pretargeted Radioimmunotherapy of Cancer / Robert M Sharkey, David G Goldenberg -- Targeted Auger Electron Radiotherapy of Malignancies / Raymond M Reilly, Amin Kassis -- Viral Introduction of Receptors for Targeted Radiotherapy / Kathryn Ottolino-Perry, Judith Andrea McCart -- Preclinical Cell and Tumor Models for Evaluating Radiopharmaceuticals in Oncology / Ann F Chambers, Eva A Turley, John Lewis, Leonard G Luyt -- Radiation Biology of Targeted Radiotherapy / David Murray, Michael Weinfeld -- Dosimetry for Targeted Radiotherapy / Sui Shen, John B Fiveash -- The Bystander Effect in Targeted Radiotherapy / Carmel Mothersill, Colin Seymour -- The Role of Molecular Imaging in Evaluating Tumor Response to Targeted Radiotherapy / Norbert Avril -- The Economic Attractiveness of Targeted Radiotherapy: Value for Money? / Jeffrey S Hoch -- Selected Regulatory Elements in the Development of Protein and Peptide Targeted Radiotherapeutic Agents / Thomas R Sykes, Connie J Sykes -- Index
Summary Targeted radiotherapy relies on and exploits characteristics of cancer cells to attack tumors. Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by international
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cancer -- Radioimmunotherapy.
Monoclonal antibodies -- Therapeutic use.
Tumor proteins.
Antibodies, Monoclonal -- therapeutic use.
Neoplasms -- radiotherapy.
Peptides -- therapeutic use.
Radioimmunotherapy -- methods.
Receptors, Peptide -- therapeutic use.
Form Electronic book
Author Reilly, Raymond.
Wiley InterScience (Online service)
LC no. 2009045879
ISBN 0470243724 (cloth)
0470613203 (electronic bk.)
0470613211
1282707663
9780470243725 (cloth)
9780470613207 (electronic bk.)
9780470613214
9781282707665