| Description |
1 online resource (215 pages) |
| Contents |
Intro -- Acknowledgements -- Introduction -- Contents -- 1: Multiple Sclerosis -- 1.1 Introduction -- 1.2 Epidemiology -- 1.3 Etiopathogenesis -- 1.3.1 Genetic Susceptibility -- 1.3.2 Environmental Risk Factors -- 1.3.3 Pathology -- 1.3.4 Immunopathophysiology -- 1.4 Clinical Manifestations -- 1.4.1 Clinical Features -- 1.4.2 Clinical Phenotypes -- 1.5 Diagnostic Procedures -- 1.5.1 MRI -- 1.5.2 Cerebrospinal Fluid Examination -- 1.5.3 Evoked Potentials -- 1.5.4 Diagnostic Criteria -- 1.5.5 Differential Diagnosis -- 1.5.6 Biomarkers and Prognostic Factors |
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1.6 Treatment Approaches -- 1.6.1 DMDs for RRMS -- 1.6.2 DMDs for Progressive MS -- 1.6.3 Monitoring Treatment Response -- 1.6.4 Treatments Under Investigation -- 1.6.5 Management of Relapses -- 1.6.6 Symptomatic Treatments -- References -- 2: Pediatric Multiple Sclerosis -- 2.1 Introduction -- 2.2 Epidemiology -- 2.3 Etiopathogenesis -- 2.3.1 Genetic Risk Factors -- 2.3.2 Environmental Risk Factors -- 2.3.3 Epigenetics -- 2.3.4 Pathology -- 2.3.5 Immune Pathophysiology -- 2.4 Clinical Manifestations -- 2.4.1 The First Demyelinating Event -- 2.4.2 Pediatric MS |
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2.4.3 Disease Course -- 2.4.4 Cognitive Impairment -- 2.4.5 Fatigue, Mood, and Behavioral Disturbances -- 2.5 Diagnostic Procedures -- 2.5.1 MRI -- 2.5.2 Cerebrospinal Fluid Examination -- 2.5.3 Autoantibodies -- 2.5.4 Neurophysiological Studies -- 2.5.5 Diagnostic Criteria -- 2.5.6 Differential Diagnosis -- 2.5.7 Advanced MRI Techniques -- 2.5.8 Neurofilaments -- 2.6 Treatment Approaches -- 2.6.1 Acute Management -- 2.6.2 DMTs -- 2.6.2.1 First-Line DMTs -- 2.6.2.2 Second-Line DMTs -- 2.6.3 Treatment Monitoring -- 2.6.4 Vitamin-D Supplementation -- 2.6.5 Symptomatic Treatments |
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2.6.6 Counseling and Support -- References -- 3: Neuromyelitis Optica Spectrum Disorders -- 3.1 Introduction -- 3.2 Epidemiology -- 3.2.1 Geographic Distribution -- 3.2.2 Demographic Features -- 3.3 Etiopathogenesis -- 3.4 Clinical Manifestations -- 3.4.1 Core Clinical Characteristics -- 3.4.2 Other Manifestations -- 3.4.3 Natural History of NMOSD -- 3.4.4 Rare Phenotypes -- 3.4.5 Differential Diagnosis -- 3.5 Diagnostic Procedures -- 3.5.1 Antibody Testing -- 3.5.2 Cerebrospinal Fluid Examination -- 3.5.3 MRI Features -- 3.6 Treatment Approaches -- 3.6.1 Treatment of Relapses |
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3.6.2 Chronic Treatment (Prevention of Relapses) -- 3.6.3 Symptomatic Treatments -- References -- 4: Anti-MOG Diseases -- 4.1 Introduction -- 4.2 Epidemiology -- 4.2.1 Demographic Features -- 4.2.2 Risk Factors -- 4.3 Etiopathogenesis -- 4.4 Clinical Manifestations -- 4.4.1 Typical Clinical Findings -- 4.4.2 Natural History of Anti-MOG Disease -- 4.5 Diagnosis -- 4.5.1 Differential Diagnosis -- 4.6 Diagnostic Procedures -- 4.6.1 Antibody Testing -- 4.6.2 Cerebrospinal Fluid Examination -- 4.6.3 MRI Features -- 4.6.4 Visual Evoked Potentials and Optical Coherence Tomography |
| Summary |
This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment |
| Notes |
4.7 Treatment Approaches |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Central nervous system -- Diseases.
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Central nervous system -- Diseases -- Diagnosis.
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Central Nervous System Diseases
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Radiology.
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Medical administration & management.
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Neurology & clinical neurophysiology.
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Medical -- Neurology.
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Medical -- Practice Management & Reimbursement.
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Central nervous system -- Diseases
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Central nervous system -- Diseases -- Diagnosis
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| Form |
Electronic book
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| Author |
Rocca, Maria A
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| ISBN |
9783030386214 |
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303038621X |
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9783030386221 |
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3030386228 |
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9783030386238 |
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3030386236 |
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