| Description |
1 online resource (xii, 202 pages) : illustrations (chiefly color) |
| Contents |
Intro -- Preface -- Contents -- Introduction -- Part I: Cancer and the Central Nervous System -- Chapter 1: Neuronal Activity in Brain Tumor Pathogenesis: Adding to the Complexities of Central Nervous System Neoplasia -- Cellular Origins of Glioma -- Effect of Neuronal Activity on NSC Dynamics -- Effect of Neuronal Activity on OPC Dynamics -- Neuron-OPC Synapses -- Activity-Dependent Pathogenesis of Gliomas -- Activity-Dependent Mitogens for Glioma -- Activity-Dependent Glioma Initiation in Cancer Predisposition Syndromes -- Neuron-Glioma Synapses |
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Effect of Synaptogenic Factors on Neuron-Glioma Synapses -- Gap Junctions in Brain Tumors -- Extracellular Vesicles as Potential Activity-Dependent Factors in Brain Tumor Pathogenesis -- Targeting Neuron-Tumor Interactions in the CNS -- Conclusion -- References -- Chapter 2: Neuron-Cancer Synaptic and Other Electrical Signaling -- References -- Chapter 3: Mechanisms of Cancer-Induced Remodeling of the Central Nervous System -- Neuronal Regulation of Glioma -- Neuronal Activity-Dependent Regulation of Glioma Growth and Progression -- Molecular Mechanisms of Neuronal Regulation of Glioma Growth |
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Activity-Regulated Secretion of Paracrine Factors -- Neurotrophins -- Neurotransmitters -- Neuronal Activity-Evoked Direct Electrochemical Signaling -- Neuronal Activity-Dependent Regulation of Glioma Initiation -- Neuronal Activity-Dependent Regulation of Glioma Invasion -- Neuronally Driven Glioma-Glioma Connections -- Glioma Regulation of Neuronal Excitability -- Glioma-Induced Neuron-Neuron Connections and Network Remodeling -- Therapeutic Implications and Future Work -- References -- Part II: Cancer and the Peripheral Nervous System |
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Chapter 4: Neural Influence on Cancer Invasion and Metastasis -- Introduction -- Nerve Structure -- Influence of Cells Within Nerves on Tumor Invasion and Metastasis -- Neuronal Cells -- Direct Effect on Tumor Cells -- Effects on the Tumor Microenvironment -- Schwann Cells -- Direct Effects on Tumor Cells -- Effects on Tumor Microenvironment -- Endoneurial Macrophages -- Summary -- References -- Chapter 5: Cancer Induced Remodeling of the Peripheral Nervous System -- Tumor Profiling Promotes Differences in Innervation and Peripheral Nerve Remodeling -- Cancer-Mediated Remodeling Mechanisms |
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Remodeling by Cancer-Secreted Proteins and Cytokines -- Remodeling by Transfer of Genetic Material -- Remodeling by Cellular Stress and Dysfunction -- Recent Advancements and Future Directions -- References -- Chapter 6: Neuroimmune Interactions and Their Role in Carcinogenesis -- Introduction -- Neuronal-Dependent Immune Regulation -- Sensory Nerve-Mediated Immune Reactions -- Substance P -- Adrenergic Signaling-Mediated Immune Signaling -- Cholinergic Signaling-Mediated Immune Signaling -- The Nonneuronal Release of Neurotransmitters -- Checkpoint-Mediated Neuronal Immune Regulation |
| Summary |
This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed August 3, 2023) |
| Subject |
Nervous system -- Cancer.
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Neurosciences.
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Gliomas.
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Carcinogenesis.
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Brain Neoplasms
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Central Nervous System Neoplasms
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Glioma
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Tumor Microenvironment
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Carcinogenesis
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Nervous System Neoplasms
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Neurosciences
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Nervous system -- Cancer
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Neurosciences
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| Form |
Electronic book
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| Author |
Amit, Moran, editor
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Scheff, Nicole N., editor
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| ISBN |
9783031324291 |
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3031324293 |
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