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Author Morrow, W. John W

Title Vaccinology : Principles and Practice
Published Hoboken : John Wiley & Sons, 2012
Online access available from:
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Description 1 online resource (554 pages)
Contents Vaccinology: Principles and Practice; Contents; List of Contributors; Preface; PART 1 Introduction; CHAPTER 1 Concept and Scope of Modern Vaccines; Introduction; Triumphs and limitations of current vaccination; Modern approaches that impact vaccine design; Genomics; Improved delivery systems and adjuvants; Therapeutic vaccination; A return to attenuated organisms?; Improve existing vaccines and vaccine uptake; Hurdles and challenges for the future; Non-infectious diseases as targets for modern vaccines; Transition from research to trial; References; PART 2 Principles of Vaccine Design
CHAPTER 2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine AdjuvantsPrinciples of vaccine design: stimulation of innate immunity; Innate immune stimulators; Toll-like receptors; Non-Toll-like receptors; Practical applications for adjuvants; Action; Safety; Summary; Acknowledgements; References; CHAPTER 3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules; MHC class I and II structure; Structural composition; The peptide-binding grooves; Nonclassical MHC class I molecules; MHC molecule assembly
Mucosal-associated lymphoreticular tissueMucosal draining lymph nodes; Lamina propria; Mucosal vaccines: current strategies and ongoing challenges; Mucosal vaccines for human use; Final word; References; CHAPTER 5 Immunologic Memory: T Cells in Humans; Introduction; Generation of memory T cells; Different types of memory T cells in humans; Parameters influencing the induction of a T-cell response; Induction of T-cell memory with a vaccine; Major obstacles; Manipulating the immune response with a vaccine; Examples of vaccine-induced memory T-cell responses; Concluding remarks; Acknowledgments
Pre-peptide loading complex stage of MHC class I foldingThe peptide-loading complex and export to the cell surface; MHC class II molecules and the invariant chain; The MHC class II peptide loading complex; Peptide generation; Peptide generation in the MHC class I pathway; Peptide generation in the MHC class II pathway; Cross- and criss-cross presentation; Summary; Acknowledgments; References; CHAPTER 4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design; Introduction; Anatomy of the mucosal immune system; Players of the mucosal immune system; Mucosal epithelium
Summary Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human applicationIncludes evaluation of vaccine efficacy and safetyDetails clinical trial design, including regulatory requirements
Notes Antibody maintenance is dependent on the age of the host
Bibliography ReferencesCHAPTER 6 Immunologic Memory: B Cells; Introduction; Human evaluation of B-cell vaccine responses; Variability in antibody maintenance is dependent on the type of vaccine; Primary B-cell immune response; Secondary B-cell immune responses; Factors important for long-lived plasma cell generation; Heterogeneity of the circulating newly formed ASCs; Models of long-lived plasma cells maintenance; Heterogeneity of human memory B-cell subsets; Current schemes of classification of human memory B-cell populations; Measuring memory B-cell responses to vaccines
Notes Print version record
Subject Drugs -- Design.
Vaccination -- Methods.
Genre/Form Methods (Music)
Form Electronic book
Author Davies, D. Huw
Schmidt, Clint S
Sheikh, Nadeem A
ISBN 1118345339 (electronic bk.)
9781118345337 (electronic bk.)