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E-book

Title Combination cancer therapy : modulators and potentiators / edited by Gary K. Schwartz
Published Totowa, N.J. : Humana Press, [2005]
©2005
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Description 1 online resource (x, 284 pages) : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Targeting of the EGFR as a modulator of cancer chemotherapy / Jose Baselga -- Cyclin dependent kinase inhibitors in combination chemotherapy / Manish A. Shah and Gary K. Schwartz -- Development of protein kinase C and cyclin-dependent kinase inhibitors as potentiators of cytotoxic drug action in leukemia / Steven Grant -- Carboxyamidotriazole, an inhibitor of nonvoltage operated calcium entry : single agent and combination therapy for ovarian carcinoma / Chad M. Michener and Elise C. Kohn -- Targeted alpha particle therapy : a rational approach to drug development in hematologic diseases and solid tumors / John M. Burke, David A. Scheinberg, and Joseph G. Jurcic -- Pharmacologic modulation of fluoropyrimidines : building upon the lessons of the past / Owen A. O'Connor -- Development of inhibitors of HER2 with taxanes : new directions in breast cancer therapy / Shanu Modi, Monica N. Fornier, and Andrew D. Seidman -- Targeting nf-b to increase the activity of cisplatin in solid tumors / Don S. Dizon [and others] -- Combinations of chemotherapy and G3139, an antisense BCL-2 oligonucleotide / Luba Benimetskaya, Sridhar Nami, and C.A. Stein -- Use of animal models to evaluate signal transduction inhibitors as modulators of cytotoxic therapy / Beverly A. Teicher
Summary Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize nove
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
Print version record
Subject Apoptosis.
Cancer -- Chemotherapy.
Cancer -- Treatment.
Neoplasms -- drug therapy.
Drug Therapy, Combination.
Form Electronic book
Author Schwartz, Gary K.
LC no. 2004010543
ISBN 1588292002 (alk. paper)
1592598641
9781588292001 (alk. paper)
9781592598649