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Title Recurrent implantation failure : etiologies and clinical management / Jason M. Franasiak, Richard T. Scott Jr., editors
Published Cham, Switzerland : Springer, 2018
Online access available from:
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Description 1 online resource
Contents Intro; Preface; Contents; Contributors; Recurrent Implantation Failure; Chapter 1: Signaling Between Embryo and Endometrium: Normal Implantation; Timing of Implantation; The Endometrium; Endometrial Receptivity; Histologic Dating; Adhesion Molecules; Growth Factors and Cytokines; Matrix Metalloproteinases; HOX Genes; Prostaglandins; Cytokines; Theories of Endometrial Receptivity Defects; Summary and Conclusions; References; Chapter 2: Embryo and Endometrial Synchrony in Implantation Failure; Introduction; Pathology or Physiology; The Endometrium; The Embryo
Developmental Rate and Abnormal Kinetics in the Cleavage Stage EmbryoMorphologic Features Associated with Implantation at the Cleavage Stage; Laboratory Interventions to Improve Implantation Potential at the Cleavage Stage; Time-Lapse Imaging for Detection of Abnormal Cleavage Patterns, Abnormal Phenotypes, and Multinucleated Embryos; Assisted Hatching for Treatment of the Thick Zona Pellucida; Co-culture of Embryos; Extended Culture of Embryos to the Blastocyst Stage; Blastocyst Stage Embryos; Developmental Rate and Abnormal Kinetics in the Blastocyst
Management of Embryo and Endometrial SynchronySummary; References; Chapter 3: Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?; Male Gamete Factor, Why it Matters?; Major Male Gamete Factors in Recurrent Implantation Failure; Sperm Chromosomal Aneuploidy; Sperm DNA Damage/Sperm DNA Fragmentation (SDF); Sperm Epigenetics; Potential Therapeutic Options and Interventions; Future Directions; References; Chapter 4: Embryonic Factors Associated with Recurrent Implantation Failure; Cleavage Stage Embryos
Morphologic Features of the Blastocyst Associated with ImplantationLaboratory Interventions to Improve Implantation Potential at the Blastocyst Stage; Freeze-All Strategy; Vitrification of Blastocysts Undergoing Delayed Expansion; Other Emerging Treatment Options; Conclusions; References; Chapter 5: The Genetics of Pregnancy Failure; The Role of Genetics in Early Pregnancy Failure; Cytogenetic Findings in POCs; Chromosome Rearrangement History; Single Gene Disorders and Recurrent Pregnancy Loss; The Role of Genetics in Implantation
Preimplantation Genetic Screening (PGS): First Generation, Limited by Suboptimal Biopsy and Testing MethodologyPreimplantation Genetic Screening: Second Generation, Improved Biopsy, and Comprehensive Testing Platforms; Conclusion; References; Chapter 6: Immune Factors in Recurrent Implantation Failure; Natural Killer Cells; But What Happens in ART?; Other Immune Maternal Cells; Conclusions; References; Chapter 7: Stress and Implantation Failure; Stress-Induced Suppression of Folliculogenesis as a Cause of Implantation Failure; Stress and FHA
Summary This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists
Notes Includes index
Online resource; title from PDF title page (EBSCO, viewed April 10, 2018)
Subject Human embryo -- Transplantation.
Human reproductive technology.
Infertility, Female.
Form Electronic book
Author Franasiak, Jason M., editor
Scott, Richard T., Jr., editor
ISBN 331971967X (electronic bk.)
9783319719672 (electronic bk.)