| Description |
1 online resource (337 p.) |
| Contents |
Cover -- Half Title -- Acknowledgement -- Title Page -- Copyright Page -- Table of Contents -- List of Figures -- List of Schemes -- List of Tables -- Acknowledgements -- Preface -- Chapter 1: Allergic Contact Dermatitis to Small Molecule Xenobiotics -- 1.1 Definition of Allergic Contact Dermatitis -- 1.2 Sensitisation and Elicitation Phases of ACD -- 1.2.1 Sensitisation -- 1.2.2 Elicitation -- 1.2.3 The Roles of Keratinocytes in the Immune System -- 1.3 ACD vs Irritant Contact Dermatitis (ICD) -- 1.4 Diagnosis and Treatment of ACD -- 1.4.1 Patch Testing -- 1.4.2 Treatment of ACD |
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1.5 Epidemiology of ACD -- 1.5.1 Incidence and Prevalence Statistics for ACD in the General Population -- 1.5.2 Individuals at Risk From Chemical Allergens in the Home -- 1.5.3 Individuals at Risk From Chemical Allergens at Work -- 1.5.4 Frequency of Sensitisation to Common Allergens -- 1.6 Factors Contributing to Xenobiotic-Derived ACD -- Chapter 2: Skin Absorption of Chemical Allergens -- 2.1 Significance of Skin Absorption in Allergic Contact Dermatitis -- 2.2 Skin Barrier Function and The Stratum Corneum -- 2.3 Pathways of Allergen Absorption -- 2.4 Mechanisms of Allergen Absorption |
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2.5 The Skin Reservoir -- 2.6 Factors Influencing Allergen Absorption -- 2.6.1 Chemical Factors -- 2.6.2 Physiological Factors -- 2.7 Summary -- Chapter 3: Enzymes and Mechanisms of Xenobiotic Metabolism -- 3.1 Activation and Detoxication of Xenobiotics -- 3.2 Factors Influencing the Metabolism of a Compound -- 3.3 The Three Phases of Metabolism -- 3.3.1 Phase I Metabolism -- 3.3.2 Phase II Metabolism -- 3.3.3 Phase III Metabolism -- 3.4 Protein Processing Enzymes -- 3.5 Summary -- Chapter 4: Enzymes and Pathways of Xenobiotic Metabolism in Skin -- 4.1 Skin as a Metabolising Organ |
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4.2 Enzymology of the Skin -- 4.2.1 Overview of Enzymes Identified in Skin -- 4.2.2 Relative Activities of Hepatic and Cutaneous Enzymes -- 4.2.3 Inducibility of Cutaneous Enzyme Expression -- 4.3 Inter-Species and Inter-Individual Variability of Enzyme Expression -- 4.4 Summary -- Chapter 5: Xenobiotics as Skin Sensitisers: Metabolic Activation and Detoxication, and Protein-Binding Mechanisms -- 5.1 Binding of Xenobiotics to Biological Macromolecules -- 5.1.1 Binding of Haptens to Protein/Peptide -- 5.2 Concepts of Prohapten Activation and Hapten Detoxication |
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5.2.1 Prohapten Activation and Hapten Detoxication by Skin Metabolising Enzymes -- 5.2.2 Non-Enzymatic Xenobiotic Oxidoreduction -- 5.3 Hypothetical Biotransformations of Small Molecules in Skin -- 5.3.1 Alcohols -- 5.3.2 Aldehydes -- 5.3.3 Ketones -- 5.3.4 Carboxylic Acids -- 5.3.5 Esters -- 5.3.6 Peroxides -- 5.3.7 Salicylates -- 5.3.8 Gallates -- 5.3.9 Coumarins and Anhydrides -- 5.3.10 Amines and Nitrobenzenes -- 5.3.11 N-rings -- 5.3.12 Dyes -- 5.3.13 Substituted 5 Atom Rings -- 5.3.14 Saturated 6 Atom Rings -- 5.3.15 Sulphonates and Sulphanilic Acids -- 5.3.16 Halogenated Compounds |
| Notes |
Description based upon print version of record |
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5.3.17 Corticosteroids |
| Form |
Electronic book
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| ISBN |
9781000893779 |
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1000893774 |
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