Limit search to available items
Book Cover
E-book

Title Biosimulation in biomedical research, health care and drug development / Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan, editors
Published Vienna ; New York : SpringerWienNewYork, ©2012

Copies

Description 1 online resource (xv, 396 pages)
Contents Machine generated contents note: 1. Modeling in Biomedical Research and Health Care / Erik Mosekilde -- 2. Concepts in Mechanism Based Modeling / Erik Mosekilde -- 3. Approach to Model Building / Erik Mosekilde -- 4. Emergence of Oscillatory Dynamics / Erik Mosekilde -- 5. Conductance-Based Models for the Evaluation of Brain Functions, Disorders, and Drug Effects / Hans A. Braun -- 6. Functional Modeling of Neural-Glial Interaction / Olga V. Sosnovtseva -- 7. Activity-Related Structural Changes in the Myelinated Nerve Fiber / Georgy V. Maksimov -- 8. Closed-Loop Control of Brain Rhythms / Julien Modolo -- 9. Modeling Ca2+ Microdomains / Niels-Henrik Holstein-Rathlou -- 10. Synchronization of Cellular Contractions in the Arteriolar Wall / Niels-Henrik Holstein-Rathlou -- 11. Microvascular Plasticity / Niels-Henrik Holstein-Rathlou -- 12. Bifurcations and Multistability in Periodically Stimulated Cardiac Cells / Elena Surovyatkina -- 13. Synchronization: A Case in Biological Studies / Alexander G. Balanov -- 14. Multilevel-Modeling, Core Predictions, and the Concept of Final Conclusions / Gunnar Cedersund -- 15. Absorption Kinetics of Insulin Mixtures after Subcutaneous Administration / Morten Colding-Jørgensen -- 16. Physiologically-Based Pharmacokinetics / Amin Rostami-Hodjegan
Summary Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. The book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various cellular and physiological processes, emphasizing particularly the role of self-sustained biological activity. The way how the use of computer models allows optimization of the treatment of various diseases for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides a discussion of the use of models in the pharmaceutical industry, and presents the view of the regulatory agencies on the topic
Analysis Medicine
Pharmaceutical technology
Pharmacy
Bioinformatics
Statistics
Biomedicine
Pharmaceutical Sciences/Technology
Medicine/Public Health, general
Biophysics and Biological Physics
Computational Biology/Bioinformatics
Statistics for Life Sciences, Medicine, Health Sciences
levenswetenschappen
life sciences
geneeskunde
toegepaste statistiek
applied statistics
volksgezondheid
public health
computational science
biomedische wetenschappen
farmacologie
pharmacology
farmacie
biofysica
biophysics
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Subject Medicine -- Research -- Simulation methods
Biology -- Research -- Simulation methods
Drug development -- Simulation methods
Systems biology.
Drugs -- Design.
Chemotherapy.
Biological models.
Biomedical Research
Computer Simulation
Drug Design
Drug Therapy
Models, Biological
Systems Biology
simulation.
HEALTH & FITNESS -- Holism.
HEALTH & FITNESS -- Reference.
MEDICAL -- Alternative Medicine.
MEDICAL -- Atlases.
MEDICAL -- Essays.
MEDICAL -- Family & General Practice.
MEDICAL -- Holistic Medicine.
MEDICAL -- Osteopathy.
Drugs -- Design
Chemotherapy
Biological models
Systems biology
Form Electronic book
Author Mosekilde, Erik
Sosnovtseva, Olga
Rostami-Hodjegan, Amin
ISBN 9783709104187
3709104181