| Description |
1 online resource |
| Contents |
Aquaporin functional detection: basic concepts on water and solute permeation -- Aquaporin discovery in the genomic era -- Aquaporin structure and selectivity -- Aquaporin regulation: gating and trafficking -- Yeast aquaporins and aquaglyceroporins: a matter of life style -- Aquaporins in health -- Renal aquaporins: roles in water balance disorders -- Vasopressin and the regulation of aquaporin-2 in health and disease -- Hepatobiliary, pancreas and salivary glands aquaporins in health and disease -- Aquaporins with the central nervous system: implications for oedema following traumatic CNS injury -- Aquaporins in carcinogenesis: water and glycerol channels as new potential drug targets -- Attacking aquaporin water and solute channels of human-pathogenic parasites: new routes for treatment? -- Aquaporins: chemical inhibition by small molecules -- Drug discovery and therapeutic targets for pharmacological modulators of aquaporin channels -- Inorganic compounds as aquaporins substrates or as potent inhibitors: a coordination chemistry point of view |
| Summary |
Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. This book presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book's epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL |
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Print version record |
| Subject |
Aquaporins.
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Drug targeting.
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Drug development.
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Drugs -- Research.
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Aquaporins
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Drug Delivery Systems
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SCIENCE -- Life Sciences -- Biochemistry.
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Aquaporins
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Drug development
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Drug targeting
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Drugs -- Research
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| Form |
Electronic book
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| Author |
Soveral, Graça, editor
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Casini, Angela, editor
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Nielsen, Søren, 1962- editor.
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| ISBN |
9781498707848 |
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149870784X |
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