| Description |
1 online resource (xiii, 454 pages) : illustrations (some color) |
| Contents |
Microbial vaccines design : the reverse vaccinology approach / Roberto Rosini, Michele A. Barocchi, Rino Rappuoli -- Design and development of recombinant vaccines with viral properties / Gerd Lipowsky, Martin F. Bachmann -- Tools for vaccine design : prediction and validation of highly immunogenic and conserved class II epitopes, and development of epitope-driven vaccines / Anne S. De Groot [and others] -- Virus like-particle vaccines advantages and challenges / Ted M. Ross [and others] -- Design platforms of nanocapsules for human therapeutics or vaccines / Masaaki Kawano [and others] -- Designing immunogens for vaccine development in reference to HIV / Aemro Kassa [and others] |
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Expression and purification of recombinant proteins for vaccine applications / Carlo Zambonelli, Deeann Martinez-Guzmann, and Indresh K. Srivastava -- DNA vaccines for infectious diesase / Samuel Stepenson, Manmohan Singh, Indresh K. Srivastava -- Developing stable cell lines for the production of vaccine antigens / Xiaotian Zhong [and others] -- Spectroscopy of vaccines / C. Russell Middaugh, Sangeeta B. Joshi -- Biophysical characterization of protein antigens within vaccine formulations / Padima Malyala, Derek O'Hagan, Manmohan Singh -- Structural characteristics predict the stability of HIV / Zohar Biron [and others] -- Selection of optimal adjuvants and product factors that affect vaccine immunogenicity / Wei Wang, Manmohan Singh -- Lyophilization and stabilization of vaccines / James Chesko [and others] -- Effect of buffers and stabilizers on vaccine stability and efficacy / Shireesh P. Apte, Sydney Ugwu -- Selection of final product containers / Luis Baez, Adrian Distler -- From the lab to the clinic : filing a phase I IND for an investigational vaccine / Kenneth G. Surowitz |
| Summary |
Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experien |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Vaccines.
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Drug development.
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Drug stability.
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Vaccines -- pharmacology
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Drug Discovery -- methods
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Drug Stability
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Vaccines
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MEDICAL -- Pharmacology.
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Drug development
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Drug stability
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Vaccines
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| Form |
Electronic book
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| Author |
Manmohan Singh, 1964 November 8-
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Srivasta, Indresh K.
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| LC no. |
2010048282 |
| ISBN |
9781118023648 |
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1118023641 |
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9781118023624 |
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1118023625 |
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9781118023631 |
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1118023633 |
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1283175657 |
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9781283175654 |
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9786613175656 |
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661317565X |
|
