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Title Immune aspects of biopharmaceuticals and nanomedicines / edited by Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette
Edition First edition
Published Singapore : Pan Stanford Publishing, 2018
Online access available from:
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Description 1 online resource (xliv, 994 pages) : illustrations
Series Pan Stanford Series on Nanomedicine ; vol. 3
Pan Stanford series on nanomedicine ; v. 3
Summary "The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike. This book provides a broad survey of various interconnected topics, all accomplished in a user?friendly format. The chapters are devoted to the immune stimulatory and suppressive effects of antibodies, peptides and other biopharmaceuticals, drug carrier liposomes, micelles, polymers, polymeric vesicles, dendrimers, carbon nanotubes, and other nanomedicines (with and without surface targeting ligands). The text discusses the state of the art in nanoparticle?formulated therapeutic and preventive vaccines along with their potential molecular mechanisms underlying immunogenicity. The latter phenomenon is addressed as an adverse effect of monoclonal antibodybased biopharmaceuticals and nanomedicines. Yet another adverse immune effect of monoclonals and nanomedicines, complement activation?related pseudoallergy (CARPA), is discussed in unprecedented detail in terms of occurrence, prediction, prevention, and mechanism. The range of the contributing authors accurately reflects the diverse and rapidly evolving fields of biotherapeutics, nanomedicines, nanoimmunology, and nanotoxicology. The books multidisciplinary and in?depth approach makes it a standard reference in this expansive and interdisciplinary field."--Provided by publisher
Notes Raj Bawa, MS, PhD, is president of Bawa Biotech LLC, a biotech/pharma consultancy and patent law firm based in Ashburn, Virginia, USA (founded in 2002). He is a registered patent agent licensed to practice before the US Patent Office, scientific advisor to Teva (Israel), visiting research scholar at the Pharmaceutical Research Institute (Rensselaer, NY), and vice president of Guanine, Inc. (Rensselaer, NY). Currently, he is principal investigator of a CDC grant to develop an assay for carbapenemase-resistant bacteria. Dr. Bawa was a primary examiner at the US Patent Office from 1996 to 2002 and an adjunct professor at Rensselaer (Troy, NY) from 1998 to 2018, where he received his PhD (biochemistry/ biophysics). He has authored over 100 publications, co-edited 4 texts, and serves as an associate editor of Nanomedicine (Elsevier). Janos Szebeni, MD, PhD, DSc, is director of the Nanomedicine Research and Education Center at Semmelweis University School of Medicine in Budapest, Hungary. He is also founder and CEO of SeroScience, Ltd. (based in Boston, Massachusetts), and a full professor of immunology and biology at the University of Miskolc in Hungary. He has made significant contributions to three fields: artificial blood, liposomes, and the complement system. His original works led to the "CARPA" concept, i.e., that complement activation underlies numerous drug-induced (pseudo) allergic (infusion) reactions.Thomas J. Webster, MS, PhD (H index: 77), is the Art Zafiropoulo Professor and department chair of Chemical Engineering at Northeastern University. He has graduated or supervised over 109 visiting faculty, clinical fellows, post-doctoral students, and thesis completing BS, MS, and PhD students. He is the founding editor-in-chief of the International Journal of Nanomedicine and a past president of the U.S. Society for Biomaterials.Gerald F. Audette, PhD, has been a faculty member at York University in Toronto, Canada, in the Department of Chemistry since 2006. Currently he is associate professor in the department and a member of the Centre for Research on Biomolecular Interactions at York University. Dr. Audette is the co-editor of volumes 1-4 of the Pan Stanford Series on Nanomedicine and is a subject editor of structural chemistry and crystallography for the journal FACETS
Description based on online resource; title from digital title page (viewed on July 04, 2019)
Subject Biomedical engineering.
Biological Products -- immunology.
Biopharmaceutics -- methods.
Nanomedicine -- methods.
Nanostructures -- adverse effects.
Nanostructures -- therapeutic use.
Biomedical engineering.
HEALTH & FITNESS / Diseases / General.
MEDICAL / Biotechnology
MEDICAL / Clinical Medicine.
MEDICAL / Diseases.
MEDICAL / Evidence-Based Medicine.
MEDICAL / Immunology
MEDICAL / Internal Medicine.
SCIENCE / Biotechnology
Form Electronic book
Author Audette, Gerald F., editor.
Bawa, Raj, editor.
Szebeni, János, 1954- editor.
Webster, Thomas J., editor.
ISBN 0203731530