| Description |
1 online resource (xiv, 635 pages) : illustrations |
| Contents |
Part Part 1 Introduction -- chapter 1 Introduction -- György Kéri and István Toth / A breakthrough in modern drug research -- part Part 2 Pathomechanisms and molecular target finding -- chapter 2 Drug discovery based on functional genomics -- Gábor Mikala and István Vályi-Nagy / Target selection and validation -- chapter 3 Mapping of the human genome / Zoltán L. Marcsek -- chapter 4 Molecular diagnosis of signal transduction related diseases / István Ember -- part Part 3 Common pathway and general mechanism -- chapter 5 Signal transduction therapy / Alexander Levitzki -- chapter 6 Heat shock proteins / P ter Csermely -- chapter 7 Transcription factors as targets for drug development / Devarajan Karunagaran -- chapter 8 Apoptosis in various diseases / Béla Szende -- chapter 9 Caspases -- Pál I. Bauer, Erzs bet Kénesi and Andr's Ill's / The regulators and executioners of the apoptotic process -- chapter 10 The role of drug metabolism enzymes in signal transduction processes / József Mandl -- chapter 11 Recent developments in calcium signaling -- Greg Monteith / Implications for disease and drug development -- chapter 12 T-cell receptors and coreceptors; cytokine receptors / Andr's Falus -- chapter 13 Neuro-immune responses in different diseases role of tumor necrosis factor- and IL-I -- SZILVESZTER E. VIZI / Role of tumor necrosis factor-and IL-1 -- chapter 14 Regulation of B lymphocyte function by crosstalk between receptors with stimulatory and inhibitory activity / János Gergely -- part Part 4 Drug discovery -- chapter 15 Combinatorial chemistry / Árpád Furka -- chapter 16 Lead search, selection and optimization in silico (virtual) screening / László Ó́rfi and István Kövesdi -- chapter 17 The development of carbohydrate based therapeutics / Nicholas Drinnan -- chapter 18 Introduction to structure and ligand-based drug design / György M. Keseru, Ildik Magd and Gábor Náray-Szab -- chapter 19 Gene therapy / L'szl Kopper -- part Part 5 Molecular pathomechanism of cancer -- chapter 20 Cancer genetics / L'szl Kopper -- chapter 21 Cancer as a communication disorder / György Kóczán -- part Part 6 Infectious diseases -- chapter 22 Human immunodeficiency virus -- Chris Birch / Pathogenesis, replication strategy and the role of antiretroviral drugs -- chapter 23 Signal transduction in virus infected cells -- Peter Krajcsi / Implications for therapy -- chapter 24 The development of vaccines to prevent rheumatic fever / Colleen Olive -- chapter 25 Systemic antifungal agents / Ross P. McGeary -- part Part 7 Diseases of the central and the peripheral nervous system -- chapter 26 Mechanisms of neurodegenerative diseases / Richard Anthony Hughes -- chapter 27 Neurobiology of pain -- Maree Smith / Identification of novel targets for new pain management medications -- chapter 28 Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents / János Szolcsányi -- chapter 29 Migraine / Ilona Jelencsik -- chapter 30 Regulatory mechanisms in focal ischemic stroke / Zoltan Nagy -- chapter 31 Signal transduction abnormalities in epilepsies / P ter Hal'sz -- chapter 32 Parkinson's disease -- Michael S. Starr / Its causes and treatment -- chapter 33 Physiological role of amyloid precursor protein (APP) and -amyloid peptides B. PENKE AND T. HARKÁNY -- chapter 34 Eye diseases / PIROSKA E. RAKÓCZY, WEI-YONG SHEN AND CHRIS J. BARRY -- part Part 8 Cardiovascular diseases -- chapter 35 Atherosclerosis / Gerd Schmitz -- chapter 36 Disorders of the blood coagulation f ibrinolytic system RAYMUND MACHOVICH / Raymund Machovich -- chapter 37 Angiogenesis / József Tímár -- part Part 9 Endocrinal and gastrointestinal disorders -- chapter 38 Diabetes and the heart / Lindsay Brown -- chapter 39 The leptin hormonal system as a target for new drugs designed to control food intake and body weight / Andrew Constanti -- chapter 40 Regulation of gastric secretion, Helicobacter pylori and inflammation of the gastric epithelium / L'szl Pr nai -- chapter 41 Osteoporosis / György M. Keseru -- part Part 10 Drug applications -- chapter 42 Modulation of drug effects by ABC transporters / Gergely Szakács -- chapter 43 Peptide or protein based drug delivery and targeting systems / Ferenc Hudecz -- chapter 44 Current approaches to peptidomimetics / Michael J. Kelso -- chapter 45 Drug delivery systems utilizing lipids and sugars / Allan Wong -- chapter 46 Pharmacokinetic-pharmacodynamic modeling and an example of its application to drug delivery / Edward J. Triggs |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Print version record |
| Subject |
Pathology, Molecular.
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Molecular pharmacology.
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Drugs -- Design.
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Chemotherapy.
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Molecular structure.
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Drug Design
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Drug Therapy
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Molecular Structure
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Pharmaceutical Preparations -- chemical synthesis
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Pharmacology, Clinical -- trends
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Pathology, Molecular
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molecular structure.
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MEDICAL -- Pathology.
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MEDICAL -- Pathophysiology.
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Molecular structure
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Chemotherapy
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Drugs -- Design
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Molecular pharmacology
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Pathology, Molecular
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| Form |
Electronic book
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| Author |
Kéri, György, 1950-
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Tóth, István, 1946-
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| LC no. |
2002035742 |
| ISBN |
020321997X |
|
9780203219973 |
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