Book Cover
E-book
Author Todd, Adam A., 1982- author

Title Anticancer therapeutics : from drug discovery to clinical applications / Dr. Adam A. Todd, Professor Paul W. Groundwater, Dr. Jason Gill
Edition First edition
Published Hoboken, NJ : Wiley, 2017

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Description 1 online resource
Contents Intro -- Title Page -- Copyright Page -- Contents -- Preface -- Section 1 Introduction -- Chapter 1.1 The Global Burden of Cancer -- References -- Chapter 1.2 Cancer Staging and Classification -- 1.2.1 Benign Tumour (or neoplasm) -- 1.2.2 Malignant Tumour (or cancer) -- 1.2.3 Tumour Nomenclature and Classification -- 1.2.4 Cellular Differentiation and Tumour Grade -- 1.2.5 Tumour Invasion and Metastasis -- 1.2.6 Clinical Staging of Cancer -- References -- Chapter 1.3 Cellular and Molecular Basis of Cancer -- 1.3.1 Oncogenes -- 1.3.2 Tumour Suppressor Genes -- 1.3.3 Role of Epigenetics and Gene Promoter Regulation in Tumourigenesis -- 1.3.4 Multistage Tumourigenesis -- 1.3.5 Oncogene Addiction -- 1.3.6 Hallmarks of Cancer -- 1.3.7 Principles of Cancer Treatment -- References -- Section 2 The Anticancer Agents -- Chapter 2.1 Agents Which Act Directly on DNA -- 2.1.1 Nitrogen Mustards and Nitrosoureas -- References -- 2.1.2 Temozolomide -- References -- 2.1.3 Platinum-containing agents -- References -- 2.1.4 Gemcitabine -- References -- 2.1.5 Camptothecin and Its Analogues -- References -- 2.1.6 Podophyllotoxins -- References -- 2.1.7 Anthracyclines [1] -- References -- 2.1.8 Epigenetic Targeting Agents [1] -- References -- Chapter 2.2 Antimetabolites -- 2.2.1 Cytarabine -- References -- 2.2.2 Methotrexate -- References -- 2.2.3 5-Fluorouracil -- References -- 2.2.4 6-Mercaptopurine -- References -- Chapter 2.3 Antimicrotubule agents -- 2.3.1 Taxanes -- References -- 2.3.2 Vinca Alkaloids -- References -- Chapter 2.4 Anti-hormonal agents -- 2.4.1 Bicalutamide -- References -- 2.4.2 Tamoxifen -- References -- 2.4.3 Anastrozole [1] -- References -- Chapter 2.5 Kinase Inhibitors -- 2.5.1 Discovery -- 2.5.2 Synthesis -- 2.5.3 Mode of Action -- 2.5.4 Mechanism of Resistance [32] -- 2.5.5 Adverse Drug Reactions -- References -- Section 3 The Cancers
Chapter 3.1 Breast Cancer -- 3.1.1 Epidemiology -- 3.1.2 Presentation -- 3.1.3 Diagnosis -- 3.1.4 Staging -- 3.1.5 Treatments -- References -- Chapter 3.2 Colorectal cancer -- 3.2.1 Epidemiology -- 3.2.2 Presentation -- 3.2.3 Diagnosis -- 3.2.4 Staging -- 3.2.5 Treatments -- References -- Chapter 3.3 Leukaemia -- 3.3.1 Epidemiology -- 3.3.2 Presentation -- 3.3.3 Diagnosis -- 3.3.4 Staging -- 3.3.5 Treatments -- References -- Chapter 3.4 Lung cancer -- 3.4.1 Epidemiology -- 3.4.2 Presentation -- 3.4.3 Diagnosis -- 3.4.4 Staging -- 3.4.5 Treatments -- References -- Chapter 3.5 Oesophageal Cancer -- 3.5.1 Epidemiology -- 3.5.2 Presentation -- 3.5.3 Diagnosis -- 3.5.4 Staging -- 3.5.5 Treatments -- References -- Chapter 3.6 Ovarian cancer -- Key points -- 3.6.1 Epidemiology -- 3.6.2 Presentation -- 3.6.3 Diagnosis -- 3.6.4 Staging -- 3.6.5 Treatments -- References -- Chapter 3.7 Pancreatic Cancer -- 3.7.1 Epidemiology -- 3.7.2 Presentation -- 3.7.3 Diagnosis -- 3.7.4 Staging -- 3.7.5 Treatments -- References -- Chapter 3.8 Prostate Cancer -- 3.8.1 Epidemiology -- 3.8.2 Presentation -- 3.8.3 Diagnosis -- 3.8.4 Staging -- 3.8.5 Treatments -- References -- Chapter 3.9 Skin Cancers -- 3.9.1 Epidemiology -- 3.9.2 Presentation -- 3.9.3 Diagnosis -- 3.9.4 Staging -- 3.9.5 Treatments -- References -- Chapter 3.10 Testicular cancer -- 3.10.1 Epidemiology -- 3.10.2 Presentation -- 3.10.3 Diagnosis -- 3.10.4 Staging -- 3.10.5 Treatments -- References -- Index -- EULA
Summary An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents-their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers.-Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics -Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology -Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect -Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Antineoplastic agents -- Development.
Antineoplastic agents -- Design
Antineoplastic agents -- Therapeutic use
Antimitotic agents.
Antineoplastic agents.
Neoplasms -- drug therapy
Neoplasms -- physiopathology
Antineoplastic Agents
Drug Discovery
Antimitotic Agents
SCIENCE -- Chemistry -- Industrial & Technical.
Antineoplastic agents
Antimitotic agents
Antineoplastic agents -- Design
Antineoplastic agents -- Development
Antineoplastic agents -- Therapeutic use
Form Electronic book
Author Groundwater, Paul W., author
Gill, Jason, 1973- author
LC no. 2017025861
ISBN 9781118696217
1118696212
9781118696194
1118696190
9781118696200
1118696204