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Author Sierra, Miguel A. (Miguel Angel), author

Title More dead ends and detours : en route to successful total synthesis / Miguel A. Sierra, María C. de la Torre, and Fernando P. Cossío
Edition First edition
Published Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2013
©2013
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Description 1 online resource (xxi, 266 pages) : illustrations
Contents The Inertia of Conventional Functional Groups -- The Diels-Alder Reaction -- The Aldol Condensation -- Cyclizations: Concerted, Radical, or Polar? -- Macrocycles: From Reluctant Ring Closure to Reluctant Ring Opening -- Stereochemistry, Controlled or Uncontrolled? -- Transition Metal-Mediated Transformations vs "Conventional" Reactions -- When Metathesis Fails -- Oxidations in C-C Bond Building -- The Failure of Epoxide Ring Opening and the Limits of Cascade Reactions
Summary Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity
Notes Edition statement from first page of chapter PDFs
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (viewed May 7, 2014)
Subject Organic compounds -- Synthesis.
Form Electronic book
Author Cossío, Fernando P., author
Torre, María C. de la, author
ISBN 1299738109
3527654623 (electronic bk.)
3527654631 (mobi)
352765464X (ePub)
3527654658 (ePDF)
9781299738102
9783527654628 (electronic bk.)
9783527654628 (oBook)
9783527654635 (mobi)
9783527654642 (ePub)
9783527654659 (ePDF)