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E-book
Author Lewis, Thomas J., 1959- author

Title The end of Alzheimer's : the brain and beyond / Thomas J. Lewis nand Clement L. Trempe
Edition Second edition
Published London : Academic Press, an imprint of Elsevier, [2017]
©2017
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Description 1 online resource (484 pages) : illustrations
Contents Cover; Title page; Copyright page; Dedication; Contents; About the Authors; Foreword; By Jack C. de la Torre, MD, PhD; By Kimer S. McCully, MD; Preface; By Dr. Lewis; By Dr. Trempe; Chapter 1 -- Is it Alzheimer's Disease?; Neurodegenerative Diseases and Dementia; True Dementias; Alzheimer's Disease; Alzheimer's Versus Dementias; Multifactorial Alzheimer's; What if Alzheimer's Is Not Isolated to the Brain?; Differential Diagnosis; Beta-Amyloid and Alzheimer's; Diseases That Occur With Alzheimer's; Impact of Alzheimer's; Treatable Dementias and "Senior Moments"; Head Injury; Acute Infections
Diagnosis ExploredMisdiagnosis; Prevalence of Misdiagnosis; Why Does Misdiagnosis Occur?; Patient; Doctor; Doctors Are Not the Problem; Causes of Misdiagnosis; Preventing Misdiagnosis; A 300-Billion Diagnostic Error; Baseline Disease 1-Pellagra; Baseline Disease 2-Tuberculosis; Baseline Disease 3-Typhoid Fever; Statins and Cardiovascular Disease; Statins Trigger Memory Problems; Link Between Low Cholesterol and Mortality; Cholesterol and Alzheimer's Disease; Misdiagnosis: Case Study; References; Chapter 5 -- Can Medicine Save You?; Do We Need Drugs to Be Healthy?
Mini-Mental State ExaminationMini-Cog; Mood Assessment; Brain Imaging; Objective Evaluation: Standard-of-Care; The First Alzheimer's Diagnosis; Standard-of-Care Diagnosis at Autopsy; Cognitive Tests and Human Memory; Cognitive Functioning Tests Explored; The Mini-Mental State Examination; Neurological Tests Beyond the MMSE; Limits of Cognitive Tests; Advanced Diagnosis Within the Standard-of-Care; Advanced Brain Imaging; Magnetic Resonance Imaging; Positron Emission Tomography; X-Ray Computer Tomography Scan; Who Creates Diagnostic Criteria?; References; Chapter 4 -- Diagnostic Accuracy
Normal Pressure HydrocephalusSimple Hydrocephalus; Brain Tumors; Toxic Exposure; Metabolic Disorders; Hormone Disorders; Poor Oxygenation (Hypoxia); Blood Pressure; Drug Reactions, Overuse, or Abuse; Nutritional Issues; Sodium Deficiency; Chronic Alcoholism; Other Neurodegenerative Disorders; Vascular Dementia; Parkinson's Disease; Lewy Body Dementia; Huntington's Disease; Creutzfeldt-Jakob Disease; Pick's Disease (Frontotemporal Dementia); Conclusions; References; Chapter 2 -- The Amyloid Cascade Hypothesis; Evidence Against the Amyloid Cascade Hypothesis
Research Opposed to the Amyloid Cascade HypothesisDrug Companies Committed to the Amyloid Hypothesis; Eli Lilly; Johnson & Johnson and Pfizer; Bristol-Myers Squibb; Pfizer and Medivation; Merck; The Animal Model for Alzheimer's and Beta-Amyloid Therapy; If Not Amyloid, What Next?; What Use Does Amyloid Serve? Diagnostics; Tau-Neurofibrillary Tangles: The "Other" Hallmark; Proposed Tau Therapies; Hyperphosphorylated Tau Occurs Naturally in Healthy Animals; References; Chapter 3 -- Diagnosis of Alzheimer's-Standard-of-Care; Alzheimer's Diagnosis: Standard-of-Care; Mental Status Tests
Summary The End of Alzheimer's: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer's outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer's disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer's outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer's, and will hopefully redirect many into new avenues of cellular research and discovery
Notes The Commercialization of Health Care
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Alzheimer's disease.
Alzheimer Disease.
Form Electronic book
Author Trempe, Clement L.
ISBN 0128121130 (electronic bk.)
9780128121139 (electronic bk.)