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Title Misbehaving proteins : protein (mis)folding, aggregation, and stability / edited by Regina M. Murphy, Amos M. Tsai
Published New York : Springer, [2006]
Online access available from:
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Description 1 online resource (viii, 353 pages) : illustrations
Contents Protein Folding, Misfolding, Stability, and Aggregation -- Mathematical Models and Computational Methods -- Nonnative Protein Aggregation -- Simulations of Protein Aggregation -- Experimental Methods -- Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry -- Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development -- Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales -- Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation -- X-ray Diffraction for Characterizing Structure in Protein Aggregates -- Glass Dynamics and the Preservation of Proteins -- Fundamental Studies in Model Systems -- Folding and Misfolding as a Function of Polypeptide Chain Elongation -- Determinants of Protein Folding and Aggregation in P22 Tailspike Protein -- Factors Affecting the Fibrillation of?-Synuclein, a Natively Unfolded Protein -- Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation -- Protein Product Development -- Self-Association of Therapeutic Proteins -- Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation
Summary Provides a collection of theoretical and experimental studies into protein folding, misfolding, aggregation, and stability. This work illustrates the issues faced during the development of protein products. It contains papers that cover advances in computational efforts to examine protein aggregation
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cell aggregation.
Protein folding.
Protein Folding.
Cell Aggregation.
Form Electronic book
Author Murphy, Regina M.
Tsai, Amos M.
LC no. 2005938663
ISBN 0387305084 (Cloth)
9780387305080 (Cloth)