Title Bipolar disorder vulnerability : perspectives from pediatric and high-risk populations / edited by Jair C. Soares, Consuelo Walss-Bass, Paolo Brambilla

Published London : Academic Press, an imprint of Elsevier, [2018] ©2018

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Description 1 online resource : illustrations Contents The bipolar prodrome -- Staging models and neuroprogression in bipolar disorder -- Influence of early childhood trauma on risk for bipolar disorder -- Gene-environment interactions in high-risk populations -- Genetic risk in adult family members of patients with bipolar disorder -- Neurobiological markers of stress in youth at risk for bipolar disorder -- Neurobiological markers of stress in youth at risk for bipolar disorder -- Neuroimaging findings in youth at risk for bipolar disorder -- Neurocognitive findings in youth at high risk for bipolar disorder: potential endophenotypes? -- Neuropsychological and social cogitive function in young people at genetic risk of bipolar disorder -- Cognitive and neural basis of hypomania: perspectives for early detection of bipolar disorder -- Early pharmacological interventions in youth -- Psychological interventions in offspring of parents with bipolar disorder -- Summary and integration of current findings: a model for bipolar disorder development Summary Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomicsExamines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorderExplores the interaction between genomic and environmental influences that shape behavior Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (EBSCO, viewed June 18, 2018) Subject Bipolar disorder -- Etiology Bipolar disorder in children Bipolar disorder in adolescence Children. Bipolar Disorder Genetic Predisposition to Disease Risk Factors Child Adolescent children (people by age group) HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Children Bipolar disorder in adolescence Bipolar disorder in children Form Electronic book Author Soares, Jair C., editor. Walss-Bass, Consuelo, editor Brambilla, Paolo, editor. ISBN 9780128125601 0128125608 0128123478 9780128123478

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