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Book Cover
Streaming video
Author Weksberg, Rosanna, speaker

Title Imprinting disorders associated with molecular changes on chromosome 11p15 / Rosanna Weksberg
Published London : Henry Stewart Talks, 2014
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  

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Description 1 online resource (1 streaming video file (37 min.) : color, sound)
Series Molecular genetics of human disease, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Molecular genetics of human disease
Contents Contents: What is epigenetics? -- Epigenetic regulation forms the molecular basis for genomic imprinting -- What is genomic imprinting -- Imprinted genes in early development -- Genomic organization of imprinted genes -- Imprinting center -- Imprinted domain 1 on chromosome 11p15.5 -- Complexity of imprinted clusters -- Beckwith-Wiedemann syndrome (BWS) -- BWS: a complex, clinically heterogeneous disorder -- Molecular basis of BWS -- Etiology of the Beckwith-Wiedemann syndrome -- Molecular alterations associated with BWS -- Frequency of molecular alterations in BWS -- The risks to subfertile/ART treated parents -- Subfertility/assisted reproductive technologies (ART) -- BWS molecular defects -- Multiple phenotypes associated with somatic mosaicism for 11p15 UPD -- Somatic mosaicism -- Isolated hemihyperplasia -- High level constitutional UPD -- BWS molecular testing strategies -- Laboratory testing for BWS -- MS-MLPA -- Expected methylation results from MS-MLPA -- MLPA molecular testing for BWS -- Cancer risk & surveillance -- Prenatal testing options -- Current challenges in BWS molecular testing -- Frequency of CNVs according to methylation pattern -- Monozygotic twins and BWS -- Isolated hemihyperplasia -- Current challenges in chromosome 11p15 molecular testing -- Russell-Silver syndrome (RSS -- Chromosomal regions associated with RSS -- Targeted assays of multiple imprinted loci-BWS -- Different combinations of epigenetic alterations associated with variations in clinical phenotype -- Imprint deregulation causing disease in humans
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
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Subject Epigenetics.
Genetic disorders.
Genomic imprinting.
Medical genetics.
Molecular genetics.
Beckwith-Wiedemann Syndrome.
Chromosomes, Human, Pair 11 -- genetics.
Epigenesis, Genetic.
Genomic Imprinting -- genetics.
Molecular Diagnostic Techniques.
Mosaicism.
Silver-Russell Syndrome.
Genre/Form Video recordings.
Form Streaming video