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Title Sustainable catalysis : challenges and practices for the pharmaceutical and fine chemical industries / edited by Peter J. Dunn, Pfizer Green Chemistry Lead, Sandwich, Kent, United Kingdom, K.K. (Mimi) Hii, Imperial College London, South Kensington, London, United Kingdom, Michael J. Krische, University of Texas at Austin, Austin, Texas, United States of America, Michael T. Williams, CMC Consultant, Deal, Kent, United Kingdom
Published Hoboken, New Jersey : Wiley, [2013]
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Contents Catalytic Reduction of Amides Avoiding LiAlH OR BH / Deborah L Dodds, David J Cole-Hamilton -- Hydrogenation of Esters / Lionel A Saudan -- Synthesis of Chiral Amines Using Transaminases / Nicholas J Turner, Matthew D Truppo -- Development of A Sitagliptin Transaminase / Jacob M Janey -- Direct Amide Formation Avoiding Poor Atom Economy Reagents / Benjamin M Monks, Andrew Whiting -- Industrial Applications of Boric Acid And Boronic Acid-Catalyzed Direct Amidation Reactions / Joanne E Anderson, Jannine Cobb, Roman Davis, Peter J Dunn, Russ N Fitzgerald, Alan J Pettman -- OH Activation for Nucleophilic Substitution / Jonathan MJ Williams -- Application of A Redox-Neutral Alcohol Amination in The Kilogram-Scale Synthesis of A GlyT1 Inhibitor / Martin A Berliner -- Olefin Metathesis: From Academic Concepts to Commercial Catalysts / Justyna Czaban, Christian Torborg, Karol Grela -- Challenge and Opportunity in Scaling-Up Metathesis Reaction: Synthesis of Ciluprevir (BILN 2061) / Nathan Yee, Xudong Wei, Chris Senanayake -- C-H Activation of Heteroaromatics / Koji Hirano, Masahiro Miura -- The Discovery of A New Pd/Cu Catalytic System For C-H Arylation and Its Applications in A Pharmaceutical Process / Jinkun Huang, Xiang Wang, Johann Chan -- Diarylprolinol Silyl Ethers: Development and Application As Organocatalysts / Hiroaki Gotoh, Yujiro Hayashi -- Organocatalysis for Asymmetric Synthesis: From Lab To Factory / Feng Xu -- Catalytic Variants of Phosphine Oxide-Mediated Organic Transformations / Stephen P Marsden -- Formation of C-C BONDS via Catalytic Hydrogenation and Transfer Hydrogenation / Joseph Moran, Michael J Krische
Summary Opens the door to the sustainable production of pharmaceuticals and fine chemicals Driven by both public demand and government regulations, pharmaceutical and fine chemical manufacturers are increasingly seeking to replace stoichiometric reagents used in synthetic transformations with catalytic routes in order to develop greener, safer, and more cost-effective chemical processes. This book supports the discovery, development, and implementation of new catalytic methodologies on a process scale, opening the door to the sustainable production of pharmaceuticals and fine chemicals. Pairing contributions from leading academic and industrial researchers, Sustainable Catalysis focuses on key areas that are particularly important for the fine chemical and pharmaceutical industries, including chemo-, bio-, and organo-catalytic approaches to C-H, C-N, and C-C bond-forming reactions. Chapters include academic overviews of current innovations and industrial case studies at the process scale, providing new insights into green catalytic methodologies from proof-of-concept to their applications in the synthesis of target organic molecules. Sustainable Catalysis provides the foundation needed to develop sustainable green synthetic procedures, with coverage of such emerging topics as: Catalytic reduction of amides avoiding LiAlH4 or B2H6 Synthesis of chiral amines using transaminases Industrial applications of boric acid and boronic acid catalyzed direct amidation reactions C-H activation of heteroaromatics Organocatalysis for asymmetric synthesis Offering a balanced perspective on current limitations, challenges, and solutions, Sustainable Catalysis is recommended for synthetic organic chemists seeking to develop new methodologies and for industrial chemists dedicated to large-scale process development
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Green chemistry
Chemical engineering
Catalysts
Pharmaceutical industry -- Waste minimization
SCIENCE -- Chemistry -- Physical & Theoretical.
Catalysts.
Chemical engineering.
Green chemistry.
Form Electronic book
Author Dunn, Peter J. (Peter James), editor
Hii, K. K., 1969- editor
Krische, Michael J., editor
Williams, Michael T. (Michael Trevelyan), editor
LC no. 2012050315
ISBN 9781118354513 (epub)
1118354516 (epub)
9781118354506 (pdf)
1118354508 (pdf)
9781118354490 (mobi)
1118354494 (mobi)
9781118354520 (electronic bk.)
1118354524 (electronic bk.)
1118155424 (cloth)
9781118155424 (cloth)
9781299402485 (MyiLibrary)
1299402488 (MyiLibrary)
(cloth)
1523111062
9781523111060