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Title Multiple sclerosis immunology : a foundation for current and future treatments / Takashi Yamamura, Bruno Gran, editors
Published New York : Springer, 2013
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Contents Th17 cells in autoimmune inflammation and demyelination in the central nervous system / Vijay K. Kuchroo and Thomas Korn -- Regulatory T cells in MS / Barbara B. Gawlik and David A. Hafler -- T-bet: A critical regulator of encephalitogenic T Cells / Amy E. Lovett-Racke and Michael K. Racke -- Antigen-presenting cells in the Central Nervous System / Nathalie Koning, Juan M. Ilarregui and Juan J. GarcĂ­a-Vallejo -- The role of B cells in multiple sclerosis / Bernhard Hemmer, Markus C. Kowarik and Martin S. Weber -- Diet, gut flora and multiple sclerosis: current research and future perspectives / Takashi Yamamura, and Sachiko Miyake -- GM-CSF in autoimmune inflammation of the central nervous system / Mohamed El-Behi, Bogoljub Ciric and Abdolmohamad Rostami -- The role of Toll-like receptors in multiple sclerosis and experimental autoimmune encephalomyelitis / Bruno Gran, Mukanthu H. Nyirenda and James Crooks -- Macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis / Manoj Kumar Mishra and V. Wee Yong -- Genetics of multiple sclerosis / Julia Y. Mescheriakova and Karim L. Kreft -- Gene expression profiling and pathway analysis for identification of molecular targets in MS / Jun-ichi Satoh -- Systems biology for the study of multiple sclerosis / Pablo Villoslada and Lawrence Steinman -- Checkpoints in the development of pathogenic and regulatory T cells in Experimental Autoimmune Encephalomyelitisa basis for current future interventions in MS / Denise C. Fitzgerald and Stephen M. Anderton -- Modeling MS in non-human primates / Prof. Dr. Bert A. 't Hart and S. Anwar Jagessar -- A novel concept of treatment in MS: targeting both oligodendrocyte death and inflammatory processes by inhibiting poly (ADP-Ribose) polymerase / Zsolt Illes, Hans Lassmann and Ferenc Gallyas Jr. -- Association of MS with other autoimmune diseases / Ali Manouchehrinia and Laura J. Edwards -- Current and future treatments of Multiple Sclerosis / Aiden Haghikia and Ralf Gold -- Targeting CD52 for the treatment of Multiple Sclerosis / Alasdair Coles and Joanne Jones -- Haematopoietic stem cells for the treatment of MS / Sofia Abrahamsson, Miriam Mattoscio and Paolo A. Muraro -- Mesenchymal stem cells for the treatment of Multiple Sclerosis. / Laura Lovato, Nicole Kerlero de Rosbo and Antonio Uccelli
Summary The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the new MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present andeven morethe future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that translation is real and not just virtual
Notes Includes index
Print version record
Subject Multiple sclerosis.
Multiple sclerosis -- Immunological aspects.
Multiple sclerosis -- Immunotherapy.
Multiple Sclerosis -- immunology.
Multiple Sclerosis.
Form Electronic book
Author Yamamura, T. (Takashi), editor
Gran, Bruno, editor
ISBN 9781461479536 (electronic bk.)
1461479533 (electronic bk.)
1461479525
9781461479529