Title Translational ADMET for drug therapy : principles, methods, and pharmaceutical applications / Souzan B. Yanni

Published Hoboken, New Jersey : John Wiley & Sons, Inc., [2015] ©2015

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Description 1 online resource Contents Translational Concept and Determination of Drug Absorption -- Distribution: Principle, Methods, and Applications -- Metabolism: Principle, Methods, and Applications -- Excretion: Principle, Methods, and Applications for Better Therapy -- Drug-Drug Interaction: From Bench to Drug Label -- General Toxicology: Principle, Methods, and Applications -- Toxicokinetics and Toxicity Testing in Drug Development -- PBPK Modeling and In Silico Prediction for ADME and Drug-Drug Interaction -- Translational Tools toward Better Drug Therapy in Human Populations -- Phase 1-Phase 3 Clinical Studies, Procedures, Responsibilities, and Documentation -- Regulatory Submission: MIST and Drug Safety Assessment Summary Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations.-Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations -Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage -Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines -Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies -Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (Wiley Online Library, viewed August 27, 2018) Subject Pharmacokinetics. Drugs -- Metabolism -- Pharmacokinetics Drugs -- Testing. Drug development. Chemotherapy. Drugs -- Side effects. Drug Evaluation, Preclinical Pharmacokinetics Drug-Related Side Effects and Adverse Reactions Pharmaceutical Preparations -- metabolism Drug Therapy MEDICAL -- Pharmacology. Drugs -- Side effects Drugs -- Testing Drug development Chemotherapy Pharmacokinetics Form Electronic book LC no. 2015011278 ISBN 9781118838419 1118838416 9781118838327 1118838327 9781118838440 1118838440 1118838270 9781118838273

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