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E-book
Author Orr, A. Wayne, author

Title Pathogenesis of atherosclerosis : from cell biology to therapeutics / A. Wayne Orr and Arif Yurdagul Jr., Brijesh M. Patel
Published San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014
Online access available from:
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Description 1 online resource (1 PDF (xi, 125 pages)) : illustrations
Series Colloquium series on integrated systems physiology, 2154-5626 ; # 53
Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology ; # 53. 2154-5626
Contents 1. Introduction to atherosclerosis -- 1.1 Vessel structure and atherosclerosis -- 1.2 Defining atherosclerotic plaque progression
2. Epidemiology -- 2.1 Cardiovascular disease mortality -- 2.1.1 Ischemic heart disease -- 2.1.2 Stroke -- 2.1.3 Peripheral artery disease (PAD) -- 2.2 Risk factors -- 2.2.1 Dyslipidemia -- 2.2.2 Diabetes mellitus -- 2.2.3 Smoking -- 2.2.4 Hypertension -- 2.2.5 Advancing age -- 2.2.6 Genetics -- 2.2.7 Other risk factors
3. Endothelial cell activation and arterial hemodynamics -- 3.1 Endothelial cell dysfunction and activation -- 3.2 Mechanical forces in the vessel wall -- 3.3 Endothelial shear stress and plaque localization -- 3.4 Transducing shear stress into biochemical signals -- 3.5 Conclusions
4. Cholesterol and cardiovascular disease -- 4.1 A historical perspective -- 4.2 Cholesterol biosynthesis and trafficking -- 4.2.1 Low-density lipoproteins -- 4.2.2 High-density lipoproteins -- 4.2.2.1 HDL biosynthesis -- 4.2.3 Maintaining cholesterol homeostasis -- 4.3 "Good cholesterol" and "Bad cholesterol."
5. Inflammation in atherosclerosis -- 5.1 Leukocyte adhesion cascade -- 5.2 Roles of specific leukocyte populations -- 5.2.1 Monocytes and macrophages -- 5.2.2 Dendritic cells -- 5.2.3 Neutrophils -- 5.2.4 Mast cells -- 5.2.5 T lymphocytes -- 5.2.6 B-cells
6. Smooth muscle cells and plaque vulnerability -- 6.1 Smooth muscle driven fibrosis in the growing plaque -- 6.2 Plaque stenosis versus thrombosis -- 6.3 Responses driving vessel stiffening in atherosclerosis -- 6.4 Plaque destabilization and the inflammatory response -- 6.5 Atherosclerotic plaque calcification
7. Diagnosing atherosclerotic disease -- 7.1 Ischemic heart disease -- 7.1.1 Stable ischemic heart disease -- 7.1.2 Acute coronary syndrome -- 7.2 Ischemic stroke -- 7.3 Peripheral artery disease (PAD)
8. Treatment and prevention -- 8.1 Primary prevention -- 8.1.1 Treating hyperlipidemia -- 8.1.2 Treating diabetes mellitus -- 8.1.3 Treating hypertension -- 8.1.4 Treating obesity -- 8.1.5 Treating smoking -- 8.2 Treatment of established atherosclerotic cardiovascular disease -- 8.2.1 Secondary prevention -- 8.2.2 Anti-platelet therapy -- 8.2.3 Treatment of angina and claudication -- 8.2.4 Invasive surgical interventions -- 8.2.4.1 Coronary revascularization -- 8.2.4.2 Carotid revascularization -- 8.2.4.3 Peripheral artery revascularization -- 8.3 Treatment of acute cardiovascular events -- 8.3.1 Pharmacological interventions for acute coronary syndrome -- 8.3.2 Pharmacological interventions for stroke -- 8.3.3 Pharmacological interventions for acute limb ischemia -- 8.3.4 Invasive interventions for acute cardiovascular events -- 8.3.4.1 Coronary revascularization using PCI or CABG
9. Summary and future perspectives -- References -- Author biographies
Summary The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up of fat, inflammatory cells, and fibrotic tissue in the vessel wall, hinders this function, resulting in inadequate perfusion of the target tissue. Hypoxia, or lack of oxygen, rapidly results in cellular dysfunction that profoundly affects the functionality of the overall tissue. Atherosclerosis-associated tissue ischemia and hypoxia because of loss of blood flow underlies several significant disease pathologies including ischemic heart disease, stroke, and peripheral artery disease. In this eBook, we examine the process of atherosclerotic plaque formation both at the cellular level and the level of clinical presentation. Through this book, we hope to impart to the reader a better understanding of how vessel structure, environmental risk factors, and genetic predisposition contribute to atherosclerotic disease and how current and future therapies seek to circumvent the cellular processes contributing to plaque formation to reduce atherosclerotic plaque burden and clinical complications
Analysis atherosclerosis
cholesterol
endothelial
fibrosis
hemodynamics
inflammation
leukocyte
vascular cell biology
Notes Part of: Colloquium digital library of life sciences
Title from PDF title page (viewed on August 17, 2014)
Bibliography Includes bibliographical references (pages 89-123)
Subject Atherosclerosis.
Arteriosclerosis.
Form Electronic book
Author Patel, Brijesh M., author
Yurdagul, Arif, author
ISBN 1615046577 (electronic bk.)
9781615046577 (electronic bk.)
(print)