Title Immune biology of allogeneic hematopoietic stem cell transplantation : models in discovery and translation / [edited by] Gerard Socié, Robert Zeiser, Bruce R. Blazar

Edition Second edition Published London ; San Diego, CA : Academic Press, [2019]

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Description 1 online resource Summary Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedsideGuides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenariosCategorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (EBSCO, viewed November 28, 2018) Subject Hematopoietic stem cells -- Transplantation Blood -- Diseases. Immunology. Graft versus host disease. Transplantation immunology. Homografts. Hematopoietic Stem Cell Transplantation Graft vs Host Disease -- immunology Transplantation Immunology Transplantation, Homologous Hematologic Diseases Allergy and Immunology Graft vs Host Disease HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Transplantation immunology Homografts Blood -- Diseases Graft versus host disease Hematopoietic stem cells -- Transplantation Immunology Form Electronic book Author Socié, Gérard, editor. Zeiser, Robert, editor Blazar, Bruce R., editor. ISBN 9780128134399 0128134399 9780128126301 0128126302

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