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Title Chinmedomics : the integration of serum pharmacochemistry and metabolomics to elucidate the scientific value of traditional Chinese medicine / edited by Xijun Wang ; associate editors, Aihua Zhang, Hui Sun
Published Amsterdam : Elsevier, 2015
©2015
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Description 1 online resource
Contents Cover; Title Page; Copyright Page; Contents; List of Contributors; About the Editor; Preface; Chapter 1 -- Origin of Chinmedomics; 1.1 -- Introduction; 1.2 -- Application and Challenges of TCM; 1.3 -- Metabolomics: An Overview; 1.4 -- Process of the Serum Pharmacochemistry of TCM; 1.5 -- Establishment and Evolution of Chinmedomics; 1.6 -- Potential Value of Chinmedomics; 1.7 -- Future Perspectives; References; Chapter 2 -- Methods and Protocols of Chinmedomics; 2.1 -- Introduction; 2.2 -- Analytical Technologies; 2.3 -- Sampling; 2.4 -- Data Extraction and Analysis
2.5 -- Marker Identification and Validation2.6 -- Correlation Analysis between Marker Metabolites and Absorbed Chemical Components; 2.7 -- Goals for Chinmedomics; 2.7.1 -- Biological Mechanisms of the TCM Syndrome; 2.7.2 -- Pharmacological Effects of Formulae; 2.7.3 -- Correlation Analysis of Formulae and Syndrome for Effective Substances; 2.8 -- Chinmedomics for Yinchenhao Tang: A Case Study; 2.9 -- Conclusions; References; Chapter 3 -- Chinmedomics Advancing Drug Discovery and Development from Yinchenhao Tang; 3.1 -- Introduction; 3.2 -- Experimental Detail; 3.2.1 -- Chemicals and Materials
3.2.2 -- Metabolomics Study3.2.2.1 -- Animals Handling; 3.2.2.2 -- Metabolomics Analysis Platform; 3.2.3 -- Constituents Analysis Using Serum Pharmacochemistry; 3.2.3.1 -- Animals; 3.2.3.2 -- Preparation of YCHT Samples for LC/MS Analysis In Vitro and In Vivo; 3.2.3.3 -- Instrumentation and Conditions; 3.2.3.3.1 -- Q-TOF/MS analysis; 3.2.3.3.2 -- Data Processing; 3.2.4 -- Correlation Analysis between Marker Metabolites and Absorbed Constituents; 3.2.5 -- Cell Test to Verify the Efficacy of Chemical Components Correlated with Therapeutic Effect; 3.2.5.1 -- Chemicals and Reagents
3.2.5.2 -- Isolation of Hepatocytes3.2.5.3 -- Cell Culture and Treatment; 3.2.5.4 -- Flow Cytometric Analysis; 3.2.5.5 -- Statistical Analyses; 3.3 -- Results and Discussions; 3.3.1 -- Metabolomics Analysis of Protective Function of YCHT; 3.3.2 -- LC/MS Analysis for YCHT Samples In Vitro and In Vivo; 3.3.2.1 -- Optimization of MS Conditions; 3.3.2.2 -- UPLC-UV-Q-TOF Analysis of YCHT; 3.3.2.3 -- UPLC-UV-Q-TOF Analysis of Plasma Sample after Oral YCHT Administration; 3.3.3 -- Correlation Analysis between Marker Metabolites and Absorbed Chemical Components
3.3.4 -- Cell Test to Verify the Therapeutic Efficacy of the Correlated Chemical Components3.4 -- Conclusions; Chapter 4 -- Chinmedomics Approach Dissects Therapeutic Properties of ShenQiWan Acting on ShenYangXu Syndrome; 4.1 -- Introduction; 4.2 -- Experimental Detail; 4.2.1 -- Chemicals and Materials; 4.2.2 -- Metabolomics Study; 4.2.2.1 -- Animal Handling; 4.2.2.2 -- Sample Collection and Preparation; 4.2.2.3 -- UPLC-Q-TOF-HDMS Analysis; 4.2.2.4 -- Metabolic Profiling and Metabolite Analysis; 4.2.3 -- Constituents Analysis In Vitro and In Vivo; 4.2.3.1 -- Animals
4.2.3.2 -- Preparation of SQW Samples for Analysis
Summary Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional med
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed July 23, 2015)
Subject Drugs, Chinese Herbal.
Medicine, Chinese Traditional.
Metabolomics.
Medicine -- China -- Philosophy -- History.
Medicine, Oriental -- Philosophy -- History.
Pharmaceutical chemistry.
Genre/Form History.
Form Electronic book
Author Sun, Hui (Of National TCM Key Laboratory of Serum Pharmacochemistry), associate editor
Wang, Xijun, 1961- editor
Zhang, Aihua (Of National TCM Key Laboratory of Serum Pharmacochemistry), associate editor
ISBN 0128031182 (electronic bk.)
9780128031186 (electronic bk.)