Machine derived contents note: General Issues. -- Misconduct and Fraud in the Empirical Sciences: History and Overview (D. Miller & M. Hersen). -- Ethics and the Nature of Empirical Science (K. Schaffner). -- Legal Responses to Allegations of Scientific Misconduct (R. Charrow & M. Saks). -- The Human Investigator Factor. -- Cardiology: The John Darsee Experience (E. Braunwald). -- Plagiarism: The Case of Elias A. K. -- Alsabti (D. Miller). -- Scientific Fraud or False Accusations? -- The Case of Cyril Burt (A. Jensen). -- Personality Factors in Scientific Fraud and Misconduct (D. Miller). -- The Consequences of Fraud (A. Poling). -- System Considerations And Safeguards. -- Academic Pressures (M. Thelen & T. DiLorenzo). -- Editorial Processes, Safeguards, and Remedies (D. Freedman). -- Institutional Review Boards: Ethical Gatekeeper (R. Cohen & A. Ciocca). -- Epilogue. -- Future Directions: A Modest Proposal (M. Hersen & D. Miller). -- Indexes