Title Methuselah flies : a case study in the evoultion of aging / Michael R. Rose, Hardip B. Passananti, Margarida Matos

Published New Jersey ; London : World Scientific Publishing, [2004] ©2004

Copies

Location	Call no.	Vol.	Availability
W'PONDS	571.878 Ros/Mfa		AVAILABLE

Description xiv, 479 pages : illustrations, ; 27 cm Contents Machine derived contents note: Part I: Creation and long-term Evolution of Methuselah Flies -- 1. The Creation of Methuselah Flies by Laboratory Evolution. 3 -- Rose, M.R. and Matos, M. -- 2. Laboratory Evolution of Postponed Senescence in Drosophila melanogaster. 10 -- Rose, M,R. (1984) Evolution 38: 1004-1010. -- 3. Quantitative Genetics of Postponed Aging in Drosophila melanogaster -- 1. Analysis of Outbred Populations. 17 -- -Hutchinson, E.W and Rose, M.R. (1991) Genetics 127: 719-727. -- 4. Long-term Laboratory Evolution of a Genetic Life-history Trade-off -- in Drosophila mielanogaster. I. The Role of Genotype-by-Environment -- Interacti on. 26 -- Leroi,A.M, Chippindale, A.. and Rose, M.R. (1994) Evolution -- 48: 1244-1257. -- 5. Evolutionary Patterns among Measures of Aging .40 -- Nusbaurn, T.J Mueller, L.D. and Rose, M.R. (1996) Exp. Gerontol. -- 31: 507-516 -- Part II: Stress, Resistance, Physiology, and Aging -- 6. Increasing Stress Resistance Often Postpones Aging. 53 -- Bradley, T.J. and Rose, M.R. -- 7. Resistance to Environmental Stress in Drosophila nelanogaster Selected -- for Postponed Senescence. 58 -- Service, PM., Hutchinson, E.W, MacKinley, M.D. and Rose, M.R. (1985) -- Physiol. Zool. 58: 380-389. -- 8. Selection on Stress Resistance Increases Longevity in Drosophila -- menlanogaster. 68 -- Rose, MR., Vu, L.N., Park, S.U. and Graves, J.L. Jr (1.992) Exp, Gerontol. -- 27 241 -250. -- 9. Metabolic Reserves and Evolved Stress Resistance in Drosophila -- melanogaster. 78 -- Djawdan, M., Chippindale, A.K., Rose, M.R. and Bradley, T.J. (1998) Physiol. -- Zool. 71: 584-594. -- 10. Physiological Mechanisms of Evolved Desiccation Resistance in -- Drosophila inelanogaster. 89 -- Gibbs, A.G., Chippindale, A.K. and Rose, M.R. (1997) J. Exp, Biol. -- 200: 1821-1832. -- 11. Postponed Aging and Desiccation Resistance in Drosophila m1elanogaster. 101 -- Nghiem, D., Gibbs, A.G., Rose, M.R. and Bradley, TJ. (2000) Ex.p. Gerontol. -- 35: 957-969. -- Part III: Reproduction, Nutrition, and Aging -- 12. Reproduction, Nutrition, and Aging. 117 -- Rose, M.R. and Chippindale, AK. -- 13. Phenotypic Plasticity and Selection in Drosophila Life-history Evolution. -- 1. Nutrition and the Cost of Reproduction. 122 -- Chippindale, A.K., Leroi, A.M., Kim, S.B. and Rose, M,R. (1993) f. Evol. Biol. -- 6: 171-193. -- 14. Metabolic Aspects of the Trade-off between Fecundity and Longevity in -- Drosophila melanogaster. 145 -- Djawdan, M., Sugiyama, T.T, Schlaeger, L.K., Bradley, T.j. and Rose, M.R. -- (1996) Physiol. Zool. 69: 176-1 195. -- 15. Phenotypic Plasticity and Selection in Drosophila Life-history Evolution. -- 2. Diet, Mates and the Cost of Reproduction. 165 -- Chippindale, A.K., Leroi, A.M., Saing, H., Borash, D.J. and Rose, M.R. (1997) -- SEvol. Biol. 10: 269-293. -- Part IV: Genetics and Molecular Biology of Methuselah Flies -- 16. Genetics and Molecular Biology. 193 -- Passananti, H.B. and Rose, M.R. -- 17. The Effect of Superoxide Dismutase Alleles on Aging in Drosophila. 198 -- Tyler, R.H., Brar, H., Singh, M., Latorre, A., Graves, J.., Mueller, L.D., -- Rose, M.R. and Ayala, Fj. (1993) Genetica 92: 143-149. -- 18. Two-dimensional Protein Electrophoretic Analysis of Postponed Aging -- in Drosophila. 205 -- Fleming, J.E., Spicer, G.S., Garrison, R.C. and Rose, M.R. (1993) Geneica -- 91: 183-198. -- 19. Allozymic Differentiation in Response to Laboratory Demographic -- Selection of Drosophila melanogaster. 221 -- Deckert-Cruz, D.j., Tyler, R.H., Landmesser, J.E. and Rose, M.R. (1997) -- Evolution 51: 865-872. -- 20. Increased hsp22 RNA Levels in Drosophila Lines Genetically Selected -- for Increased Longevity. 229 -- Kurapati, R., Passananti, H.B., Rose, M.R. and Tower, J. (2000) J. Gerontol. -- Biol. Sci. 55: B552-B559. -- 21. Electrophoretic Analysis of Methuselah Flies from Multiple Species. 237 -- Deckert-Cruz, D.J., Matzkin, L.M., Graves, J.L. Jr. and Rose, M.R. -- Part V: Reverse Evolution of Methuselah Flies -- 22. Reverse Evolution of Aging. 251 -- Rose, M.R. and Passananti, H.B. -- 23. Multiple Genetic Mechanisms for the Evolution of Senescence in -- Drosophila melanogaster. 255 -- Service, P.M., Hutchinson, ELW. and Rose, M.R. (1988) Evolution 42: 708-716. -- 24. Desiccation, Flight, Glycogen, and Postponed Senescence in Drosophila -- inelanogas ter. 264 -- Graves, J.L., Toolson, E.C., Jeong, C., Vu, L.N. and Rose, M.R. (1992) Physiol. -- Zool. 65: 268-286. -- 25. Variation in the Reversibility of Evolution. 283 -- Teot6nio, H. and Rose, M.R. (2000) Nature 408: 463-466. -- 26. Reverse Evolution of Fitness in Drosophila inelanogaster. 286 -- Teoto'nio, H., Matos, M. and Rose, M.R. (2002) J. Evol. Biol. 15: 608-617. -- 27. Reverse Evolution of Aging in Drosophila melanogaster. 296 -- Passananti, H.B., Deckert-Cruz, DJ., Chippindale, A.K., Le, B.H. -- and Rose, M.R. -- 28. Relaxed Stress Selection in Drosophila melanogaster. 323 -- Passananti, H.B., Beckman, K.A. and Rose, M.R. -- Part VI: Aging, Development, and Crowding -- 29. Aging, Development, and Crowding. 355 -- Mueller, L.D. and Rose, M.R. -- 30. Interactions between Density-dependent and Age-specific Selection in -- Drosophila melanogaster. 359 -- Mueller, L.D. Graves, f.L. and Rose, M.R. (1993) Funct. Ecol, 7: 469-479. -- 31. The Evolution of Development in Drosophila melanogaster Selected for -- Postponed Senescence. 370 -- Chippindale, A.K., Hoang, DT, Service, PRM. and Rose, M.R. (1994) -- Evolution 48: 1880-1899. -- 32. Experimental Evolution of Accelerated Development in Drosophila. -- 1. Development Speed and Larval Survival. 390 -- Chippindale, A.K., Alipaz, J!A., Chen, H.W. and Rose, M.R. (1997) -- Evolution 51: 1536-1551. -- 331 Density-dependent Natural Selection in Drosophila: Correlations between -- Feeding Rate, Development Time and Viability. 406 -- Borash, D.J., Teot6niao, H., Rose, M.R and Mueller, L.D. (2000) J.-Evol. Biol, -- 23: 181-187. -- 34. Experimental Evolution of Accelerated Development in Drosophila. -- 2. Adult Fitness and the Fast Development Syndrome. 413 -- Chippindale, AK., Alipaz J.A. and Rose, M.R Summary Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging Bibliography Includes bibliographical references and index Notes Online version of the print title System requirements: Internet connectivity, World Wide Web browser, and Adobe Acrobat reader Mode of access: World Wide Web Subject Aging -- Genetic aspects. Evolution. Author Matos, Margarida. Passananti, Hardip Brar. LC no. 2007273646 ISBN 9812387412 :

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