| Description |
xxviii, 484 pages : illustrations (some color) ; 25 cm |
| Series |
Methods and principles in medicinal chemistry ; v. 16 |
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Methods and principles in medicinal chemistry ; v. 16
|
| Contents |
Pt. I. Basic Techniques -- 1. Modern Methods for the Expression of Proteins in Isotopically Enriched Form / Heiko Patzelt, Natalie Goto, Hideo Iwai, Kenneth Lundstrom and Erhard Fernholz -- 2. Structure Calculation Using Automated Techniques / Peter Guntert -- 3. Achieving Better Sensitivity, Less Noise and Fewer Artifacts in NMR Spectra / Detlef Moskau and Oliver Zerbe -- Pt. II. NMR of Biomolecules -- 4. NMR Strategies for Protein Assignments / Volker Dotsch -- 5. NMR of Membrane-Associated Peptides and Proteins / Reto Bader, Mirjam Lerch and Oliver Zerbe -- 6. NMR of Nucleic Acids / Radovan Fiala and Vladimir Sklenar -- Pt. III. Modern Spectroscopic Techniques -- 7. Methods for the Measurement of Angle Restraints from Scalar, Dipolar Couplings and from Cross-Correlated Relaxation: Application to Biomacromolecules / Christian Griesinger -- 8. Orientational Restraints / Eva de Alba and Nico Tjandra -- 9. Scalar Couplings Across Hydrogen Bonds / Andrew J. Dingley, Florence Cordier, Victor A. Jaravine and Stephan Grzesiek -- 10. TROSY: Transverse Relaxation-Optimized Spectroscopy / Roland Riek -- 11. MAS Solid-State NMR of Isotopically Enriched Biological Samples / Philip T. F. Williamson, Matthias Ernst and Beat H. Meier -- 12. Determination of Protein Dynamics Using [superscript 15]N Relaxation Measurements / David Fushman -- Pt. IV. Tools for Investigation of Drug - Receptor Complexes and for Ligand Screening -- 13. The Determination of Equilibrium Dissociation Constants of Protein-Ligand Complexes by NMR / Gordon C. K. Roberts -- 14. Experiments in NMR-Based Screening / Carla Marchioro, Silvia Davalli, Stefano Provera, Markus Heller, Alfred Ross and Hans Senn -- 15. The Use of Spin Labels in NMR-Supported Lead Finding and Optimization / Wolfgang Jahnke -- 16. NMR of Weakly Binding Ligands / Marcel J. J. Blommers and Simon Rudisser -- 17. Isotope Filter and Editing Techniques / Gerd Gemmecker -- Pt. V. Strategies for Drug Development Using NMR -- 18. Strategies for NMR Screening and Library Design / Christopher A. Lepre -- 19. Strategies for Hit Finding Using NMR / Werner Klaus and Hans Senn -- 20. Strategies for Drug Discovery Using NMR / Marcel J. J. Blommers, Andreas Florsheimer and Wolfgang Jahnke -- 21. NMR-Based Drug Design: Approaches for Very Large Proteins / Maurizio Pellecchia, Xuemei Huang, David Meininger and Daniel S. Sem |
| Summary |
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt W?h. Edited by a former coworker of W?h, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and display |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Wiley InterScience |
| Subject |
Nuclear magnetic resonance.
|
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Pharmaceutical chemistry.
|
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Nuclear magnetic resonance spectroscopy.
|
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Drug Design.
|
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Chemistry, Pharmaceutical -- methods.
|
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Magnetic Resonance Spectroscopy -- methods.
|
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Nuclear Magnetic Resonance, Biomolecular -- methods.
|
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Protein Conformation.
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| Author |
Zerbe, Oliver.
|
| LC no. |
2003279615 |
| ISBN |
3527304657 : |
|
