1. Introduction: The Worldwide Market for Antipsychotic Drugs -- 2. Atypical Antipsychotics: Mechanisms, and Preclinical and Clinical Profiles -- 3. Review of the Clinical Development of Atypical Antipsychotic Compounds -- 4. Phase I Clinical Development and Finding the Dose: The Role of the Bridging Study -- 5. General Methodological Issues in Antipsychotic Drug Development -- 6. Special Methodological Issues in Antipsychotic Drug Development -- 7. Concluding Remarks on Drug Development