Jack D. Pressman: An Appreciation / Gerald N. Grob -- Introduction: A Stab in the Dark -- 1. Psychiatry's Renaissance: The Problem of Mental Disorder, 1921-1935 -- 2. Sufficient Promise: John F. Fulton and the Origins of Lobotomy -- 3. Certain Benefit: Initial Impressions of the Operation -- 4. Active Treatment: Somatic Therapy and State Hospital Reform -- 5. Human Salvage: Why Psychosurgery Worked in 1949 (and Not Now) -- 6. Localizing Decisions: Psychosurgery and the Art of Medicine -- 7. The Politics of Precision: The Quest for a Better Lobotomy -- 8. Medicine Controlled: Psychiatry's Evolution as a Science and a Profession -- Epilogue: The New Synthesis -- Statistical Portrait of Psychosurgery at McLean Hospital, 1938-1954 -- Codes of Patients and Physicians Cited in Chapters 3 and 6