Contents: Pt. 1. The fragile site -- Anticipation: once upon a time -- Hairpin turns: doctors and divorce -- Linkage: family ties -- Pt. 2. Hotspots -- Replication fork: motherhood -- Base pairs: like mother, like son -- Transcription and translation: speaking of love -- Repeats: obsessions -- Saltation: coming up for air -- Mutants and wild types: you and me against the world -- Vectors: what lies ahead