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Title Drug absorption studies : in situ, in vitro and in silico models / Carsten Ehrhardt, Kwang-jin Kim, editors
Published New York : Springer, [2008]
©2008
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Description 1 online resource (xxii, 696 pages) : illustrations
Series Biotechnology : pharmaceutical aspects ; v. 7
Biotechnology (Arlington, Va.) ; v. 7
Contents Front Matter; Models for Skin Absorption and Skin Toxicity Testing; Models of the Small Intestine; Drug Absorption from the Colon In Situ; In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa; In Situ and Ex Vivo Nasal Models for Preclinical Drug Development Studies; The Isolated Perfused Lung for Drug Absorption Studies; In Vitro Models for Investigations of Buccal Drug Permeation and Metabolism; In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism; In Vitro Cellular Models for Nasal Drug Absorption Studies
Summary In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient appro
Notes Published in association with AAPS Press
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drugs -- Absorption and adsorption.
Drugs -- Metabolism.
Biological Availability.
Drug Evaluation.
Models, Biological.
Pharmaceutical Preparations -- metabolism.
Form Electronic book
Author Ehrhardt, Carsten.
Kim, Kwang J.
LC no. 2007937951
ISBN 0387749004
0387749012
9780387749006
9780387749013