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Book Cover
E-book
Author Ray, Animesh, 1954-

Title Introduction to biological networks / Alpan Raval, Animesh Ray
Published Boca Raton, Fla. : CRC Press, [2013]
©2013
Online access available from:
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Description 1 online resource (xiii, 312 pages) : illustrations
Series Chapman & Hall/CRC mathematical & computational biology series
Chapman and Hall/CRC mathematical & computational biology series.
Contents The living interactome -- Experimental inference of interactions -- Prediction of physical interactions -- Metabolic networks and genetic interactions -- Testing inferred networks -- Small model networks -- Tractable models of large networks -- Network modularity and robustness -- Networks and disease
Summary "Preface In the 1940s and 1950s, biology was transformed by physicists and physical chemists, who employed simple yet powerful concepts and engaged the powers of genetics to infer mechanisms of biological processes. The biological sciences borrowed from the physical sciences the notion of building intuitive, testable, and physically realistic models by reducing the complexity of biological systems to the components essential for studying the problem at hand. Molecular biology was born. A similar migration of physical scientists and of methods of physical sciences into biology has been occurring in the decade following the complete sequencing of the human genome, whose discrete character and similarity to natural language has additionally facilitated the application of the techniques of modern computer science. Furthermore, the vast amount of genomic data spawned by the sequencing projects has led to the development and application of statistical methods for making sense of this data. The sheer amount of data at the genome scale that is available to us today begs for descriptions that go beyond simple models of the function of a single gene to embrace a systemlevel understanding of large sets of genes functioning in unison. It is no longer sufficient to understand how a single gene mutation causes a change in its product's biochemical function, although this is in many cases still an important problem. It is now possible to address how the consequences of a mutation might reverberate through the interconnected system of genes and their products within the cell"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Biological systems -- Mathematical models.
Computational biology.
Systems biology -- Mathematical models
Biological systems -- Mathematical models.
COMPUTERS -- Programming -- Algorithms.
Computational biology.
MATHEMATICS -- Probability & Statistics -- General.
SCIENCE -- Biotechnology.
SCIENCE -- Life Sciences -- Anatomy & Physiology.
Form Electronic book
Author Raval, Alpan, 1968-
ISBN 1420010360
1584884630
9781420010367
9781584884637