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Title Animal models for neurodegenerative disease / edited by Jesús Avila, Jose J. Lucas and Félix Hernández
Published Cambridge, U.K. : Royal Society Chemistry, 2011
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Description 1 online resource (xv, 290 pages) : illustrations
Series RSC drug discovery series, 2041-3203 ; no. 6
RSC drug discovery series ; 6
Contents 1. The Contribution of Transgenic Models to the Understanding of Alzheimer's Disease Progression and Therapeutic Development / Meredith A. Chabrier, Kara M. Neely, Nicholas A. Castello and Frank M. LaFerla -- 2. Animal Models of Amyloid/PS-1 Pathology / Akihiko Takashima -- 3. The Ying and Yang of the Reelin Signalling Pathway in Alzheimer's Disease Pathology / Eduardo Soriano, Daniela Rossi and Lluís Pujadas -- 4. Transgenic Mice Overexpressing GSK-3[beta] as Animal Models for Alzheimer's Disease / Félix Hernández -- t5. Invertebrate and Vertebrate Models of Tauopathies / Jügen Götz, Lars M. Ittner, Naeman N. Götz, Hong Lam and Hannah R. Nicholas -- 6. Animal Models of Parkinson's Disease / Hardy J. Rideout and Leonidas Stefanis -- 7. Animal Models and the Pathogenesis of Parkinson's Disease / José G. Castaño, Teresa Iglesias and Justo G. de Yébenes -- 8. Neuroprotection in Parkinson's Disease / Alberto Pascual, Javier Villadiego, María Hidalgo-Figueroa, Simón Méndez-Ferrer, Raquel Gómez-Díaz, Juan José Toledo-Aral and José Lopez-Barneo -- 9. Animal Models for ALS / Ritsuko Fujii and Toru Takumi -- 10. Animal Models for Huntington's Disease / Zaira Ortega and José J. Lucas -- 11. Mouse Models of Prion Protein Related Diseases / María Gasset and Adriano Aguzzi -- 12. Mouse Models of Ischemia / David C. Henshall and Roger P. Simon -- 13. A Non-transgenic Rat Model of Sporadic Alzheimer's Disease / Khalid Iqbal, Xiaochuan Wang, Julie Blanchard and Inge Grundke-Iqbal
Summary "In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders such as Alzheimer's and Huntington's disease. By reproducing some of the pathological aspects of the diseases, these studies could reveal the mechanism for their onset or development. Some of the transgenic mice can also be used as targets for testing new compounds with the potential to prevent or combat these disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics. The chapters cover disorders including: Alzheimer's disease, Parkinson's disease, Huntington's and other CAG diseases, amyotrophic lateral sclerosis (ALS), recessive ataxias, disease caused by prions, and ischemia."--Publisher description
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Alzheimer's disease -- Animal models.
Animal models in research.
Huntington's disease -- Animal models.
Nervous system -- Degeneration -- Animal models.
Parkinson's disease -- Animal models.
Disease Models, Animal.
Neurodegenerative Diseases -- physiopathology.
Form Electronic book
Author Avila, Jesús.
Hernández Perez, Félix.
Lucas, José J.
ISBN 1849732752 (electronic bk.)
9781849732758 (electronic bk.)