| Description |
1 online resource (418 pages) : illustrations |
| Contents |
Streptozotocin-induced diabetes: induction, mechanism(s), and dose dependency-- Alterations in myocardial energy metabolism in streptozotocin diabetes-- Structural and functional consequences of streptozotocin-induced diabetes on the kidney-- Physiological and pathological consequences of streptozotocin-diabetes on the heart-- The effects of experimental diabetes on the cytochrome P450 system and other metabolic pathways-- Nerve and retinal changes in experimental diabetes-- Vascular reactivity in streptozotocin-induced diabetes-- Cardiovascular function in the intact, streptozotocin-treated rat |
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Treatment and pharmacological interventions in streptozotocin diabetes-- Other models of Type I diabetes-- The neonatal streptozotocin model of diabetes-- Spontaneous insulin-dependent diabetes mellitus in nonobese diabetic mice: comparisons with experimentally induced IDDM-- The BB rat: a unique model of human Type I diabetes-- Noninsulin-dependent animal models of diabetes mellitus |
| Summary |
An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models. Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Diabetes -- Animal models
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Diseases -- Animal models.
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Diabetes Mellitus, Experimental
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Disease Models, Animal
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Diseases -- Animal models
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Diabetes -- Animal models
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| Form |
Electronic book
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| Author |
McNeill, John H
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| ISBN |
9780203756386 |
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020375638X |
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