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Book Cover
Author Gross, David R. (David Ross)

Title Animal models in cardiovascular research / David R. Gross
Edition Third edition
Published Dordrecht ; New York : Springer, [2009]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (xxv, 431 pages) : illustrations
Contents General principles of animal selection and normal physiological values -- Preanesthesia, anesthesia, chemical restraint, and the recognition and treatment of pain and distress -- Normal cardiac function parameters -- Measuring cardiac function -- Measuring vascular function and ventricular/arterial coupling dynamics -- Isolated heart preparations, problems, and pitfalls -- Cardiovascular effects of anesthetics, sedatives, postoperative analgesic agents, and other pharmaceuticals -- Naturally occurring and iatrogenic animal models of valvular, infectious, and arrhythmic cardiovascular disease -- Iatrogenic models of ischemic heart disease -- Iatrogenic, transgenic, and naturally occurring models of cardiomyopathy and heart failure -- Iatrogenic, congenic, and transgenic models of hypertension -- Naturally occurring, iatrogenic and transgenic models of atherosclerotic disease -- Animal models for the study of neurohumeral and central neural control of the cardiovascular system -- Other transgenic animal models used in cardiovascular studies
Summary This new edition of "Animal Models in Cardiovascular Research" describes historical and recent advances in our understanding of the cardiovascular system from studies conducted in a variety of animal models. Since the last edition we have witnessed an explosion in the use of both congenic and transgenic animals. The use of specific knock-in and knock-out transgenic models has resulted in an avalanche of genetic, molecular and protein-based information that, potentially, could result in an amazing new array of treatment and management options. However, the results of these studies als
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cardiovascular system -- Diseases -- Animal models.
Cardiovascular system -- Research -- Methodology
Cardiovascular Diseases.
Cardiovascular System -- drug effects.
Disease Models, Animal.
Form Electronic book
LC no. 2009927491
ISBN 0387959629 (e-isbn)
9780387959627 (e-isbn)