| Description |
1 online resource (2 volumes) : illustrations (some color) |
| Contents |
Section I: Diseases of Myelin -- Leukodystrophies: Overview and Classification -- Multiple Sclerosis: Classification and Overview -- Genetic Susceptibility and Epidemiology -- Cellular Damage and Repair in MS -- MRI Visualization of MS -- Multiple Sclerosis (General Clinical and Trials) -- Adrenoleukodystrophies -- Krabbe's Disease -- Alexander's Disease -- Pelizeaus-Merzbacher Disease -- Guillain Barre Syndrome -- Charcot-Marie-Tooth Disease -- Infectious Demyelinating Diseases -- Ischemic White Matter Damage -- Protein Misfolding as a Disease Determinant -- Section II: Animals Models of Human Disease -- Experimental Allergic Encephalomyelitis -- Experimental Models of Virus Induced Demyelination -- Model's of Krabbe's Disease -- Model's of Alexander's Disease -- Model's of Pelizeaus Merzbacher Disease -- Models of Charcot-Marie-Tooth Disease -- Section III: The Myelin Genes and Products -- Myelin Basic Protein Gene -- Proteolipid Protein Gene -- Myelin Associated Glycoprotein Gene -- Myelin Oligodendrocyte Glycoprotein Gene -- Cyclic Nucleotide Phosophohydrolase Gene -- P0 Protein Gene -- PMP 22 Gene -- The Claudin 11 Gene -- The Neurexin Gene -- The Connexin 32 Gene -- The Integrin Genes -- The Periaxin Gene -- The QK1 Gene -- Section IV: Glial Cell Development -- Invertebrate Glia -- Neural Cell Specification During Development -- Progenitor Cells of the Adult Human White Matter -- Oligodendrocyte Lineage -- Astrocyte Lineage -- Schwann Cell Development -- Olfactory Ensheathing Cells -- Section V: Glial Cell and Myelin Functional Biology -- Structure of the Myelinated Axon -- Cell Biology of Myelin Assembly -- The Transport and Assembly of Myelin Lipids -- Functional Organization of the Nodes of Ranvier -- Electrophysiologic Consequences of Myelination -- Remyelination Through Engraftment -- Remyelination by Endogenous Glia |
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v. 1. Biology -- v. 2. Disorders |
| Summary |
With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist. * Critically reviews and evaluates all the important genetic and molecular and cellular biological data on the individual myelin genes/proteins * Details the structural and functional biology of myelin, including a look at the relationship between neuronal damage and myelin damage as seen in multiple sclerosis * Includes forward-looking section on potential therapeutic interventions in myelin diseases |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Myelin Sheath -- physiology.
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Demyelinating Diseases.
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Disease Models, Animal.
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Myelin Proteins -- genetics.
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Demyelination.
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Myelin sheath -- Diseases -- Animal models.
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Myelin sheath -- Pathophysiology.
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Myelin sheath.
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| Form |
Electronic book
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| ISBN |
0124395104 |
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9780124395107 |
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