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Title Fundamentals of antimicrobial pharmacokinetics and pharmacodynamics / edited by Alexander Vinks, Hartmut Derendorf, Johan Mouton
Published New York : Springer, 2014
Online access available from:
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Description 1 online resource
Contents Part I. Basic Concepts and Principles -- Introduction to Pharmacodynamics / William A. Craig -- In Vitro and Animal PK/PD Models / William A. Craig -- Setting Clinical MIC Breakpoints from a PK/PD Point of View: It Is the Dose That Matters / Johan W. Mouton -- Principles of Applied Pharmacokinetic-Pharmacodynamic Modeling / Benjamin Wu, Sherwin K.B. Sy, Hartmut Derendorf -- Pharmacodynamic In Vitro Models to Determine the Effect of Antibiotics / Julia Michael and Aline Barth, Charlotte Kloft and Hartmut Derendorf -- Population Pharmacokinetic-Pharmacodynamic (PK/PD) Modeling of Anti-infective Agents and Its Applications to Individualized Therapy / Alexander A. Vinks -- Suppressing Resistance Development / Vincent H. Tam -- Drug-Drug Combinations / John Turnidge -- Part II. Clinically Oriented Chapters -- Aminoglycosides / Catharine C. Bulik, Charles H. Nightingale and David P. Nicolau -- Continuous Infusion of Beta-lactam Antibiotics / Anouk E. Muller and Johan W. Mouton -- Macrolides and Ketolides / Françoise Van Bambeke -- Glycopeptides / Inge C. Gyssens -- Clinical Pharmacodynamics of Quinolones / George L. Drusano, H.S. Heine and A. Louie -- Pharmacokinetics and Pharmacodynamics of Colistin / Roger L. Nation, Phillip J. Bergen and Jian Li -- Daptomycin: Pharmacokinetic, Pharmacodynamic, and Dose Optimization / Céline Vidaillac and Michael J. Rybak -- PK/PD of Oxazolidinones / Ursula Theuretzbacher -- Tigecycline / Catharine C. Bulik, Anthony M. Nicasio and Paul G. Ambrose
Foreword -- Section I: Basic Concepts and Principles -- Introduction to Pharmacodynamics and micrbiology -- In vitro and animal PK/PD model -- MIC and breakpoints -- Principles of applied PK/PD modeling -- Population Pk/PD modeling and its applications to antimicrobials -- Drug resistance and Drug-drug combinations -- Section II: Clinical -- Aminoglycosides -- Beta-lactam antibiotics including continuous infusion -- Macrolides -- Glycopeptides -- Quinolones -- Other
Summary Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Anti-infective agents -- Pharmacokinetics.
Anti-infective agents -- Dose-response relationship.
Anti-Infective Agents -- pharmacokinetics.
Form Electronic book
Author Vinks, Alexander A., editor
Derendorf, Hartmut, editor
Mouton, Johan W., editor
ISBN 9780387756134 (electronic bk.)
0387756132 (electronic bk.)